InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CXCL14

Summary

InnateDB Gene

IDBG-45673.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CXCL14

Gene Name

chemokine (C-X-C motif) ligand 14

Synonyms

BMAC; BRAK; KEC; KS1; MIP-2g; MIP2G; NJAC; SCYB14

Species

Homo sapiens

Ensembl Gene

ENSG00000145824

Encoded Proteins

IDBP-45675

chemokine (C-X-C motif) ligand 14

IDBP-482673

chemokine (C-X-C motif) ligand 14

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 25964486

CXCL14 is important for constitutive antimicrobial defences against pneumonia

Entrez Gene

Summary

This gene belongs to the cytokine gene family which encode secreted proteins involved in immunoregulatory and inflammatory processes. The protein encoded by this gene is structurally related to the CXC (Cys-X-Cys) subfamily of cytokines. Members of this subfamily are characterized by two cysteines separated by a single amino acid. This cytokine displays chemotactic activity for monocytes but not for lymphocytes, dendritic cells, neutrophils or macrophages. It has been implicated that this cytokine is involved in the homeostasis of monocyte-derived macrophages rather than in inflammation. [provided by RefSeq, Jul 2008]
This antimicrobial gene belongs to the cytokine gene family which encode secreted proteins involved in immunoregulatory and inflammatory processes. The protein encoded by this gene is structurally related to the CXC (Cys-X-Cys) subfamily of cytokines. Members of this subfamily are characterized by two cysteines separated by a single amino acid. This cytokine displays chemotactic activity for monocytes but not for lymphocytes, dendritic cells, neutrophils or macrophages. It has been implicated that this cytokine is involved in the homeostasis of monocyte-derived macrophages rather than in inflammation. [provided by RefSeq, Sep 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:135570679-135579279

Strand

Reverse strand

Band

q31.1

Transcripts

ENST00000337225	ENSP00000337065
ENST00000512158	ENSP00000423783

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008009	chemokine activity

Biological Process

GO:0006935	chemotaxis
GO:0006955	immune response
GO:0007165	signal transduction
GO:0007267	cell-cell signaling
GO:0045087	innate immune response (InnateDB)
GO:0048839	inner ear development
GO:0060326	cell chemotaxis

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005794	Golgi apparatus

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000021508

View Gene Order

ENSBTAG00000006694

Not yet available

Pathways

NETPATH

REACTOME

KEGG

hsa04060

Cytokine-cytokine receptor interaction pathway

hsa04062

Chemokine signaling pathway pathway

INOH

PID NCI

Cross-References

SwissProt

O95715

TrEMBL

UniProt Splice Variant

Entrez Gene

9547

UniGene

Hs.483444 Hs.599465 Hs.644699

RefSeq

NM_004887

HUGO

HGNC:10640

OMIM

604186

CCDS

CCDS4188

HPRD

16049

IMGT

EMBL

AC034206 AF073957 AF106911 AF144103 AK075514 AY358906 BC003513 BT007080

GenPept

AAD03839 AAD38944 AAF78449 AAH03513 AAP35743 AAQ89265 BAG52160

RNA Seq Atlas

9547