InnateDB Protein
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IDBP-45694.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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QPCT
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Protein Name
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glutaminyl-peptide cyclotransferase
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Synonyms
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GCT; QC; sQC;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000344829
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InnateDB Gene
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IDBG-45690 (QPCT)
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Protein Structure
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Function |
Responsible for the biosynthesis of pyroglutamyl peptides. Has a bias against acidic and tryptophan residues adjacent to the N-terminal glutaminyl residue and a lack of importance of chain length after the second residue. Also catalyzes N-terminal pyroglutamate formation. In vitro, catalyzes pyroglutamate formation of N-terminally truncated form of APP amyloid-beta peptides [Glu-3]-beta-amyloid. May be involved in the N-terminal pyroglutamate formation of several amyloid-related plaque-forming peptides. {ECO:0000269PubMed:15063747, ECO:0000269PubMed:18486145, ECO:0000269PubMed:21288892}.
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Subcellular Localization |
Secreted {ECO:0000269PubMed:18486145}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
13
[view]
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Protein-Protein |
12
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
GO:0006464
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cellular protein modification process
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GO:0006508
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proteolysis
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GO:0017186
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peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase
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Cellular Component |
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PDB ID |
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InterPro |
IPR007484
Peptidase M28
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PFAM |
PF04389
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q16769
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PhosphoSite |
PhosphoSite-Q16769
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
25797
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UniGene |
Hs.79033
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RefSeq |
NP_036545
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HUGO |
HGNC:9753
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OMIM |
607065
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CCDS |
CCDS1790
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HPRD |
06140
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IMGT |
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EMBL |
AC007391
AK290605
BC036721
BC047756
CH471053
X67731
X71125
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GenPept |
AAH36721
AAH47756
AAY14804
BAF83294
CAA47961
CAA50438
EAX00392
EAX00394
EAX00396
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