Version 5.4
Homo sapiens Gene: QPCT
Summary
InnateDB Gene IDBG-45690.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol QPCT
Gene Name glutaminyl-peptide cyclotransferase
Synonyms GCT; QC; sQC
Species Homo sapiens
Ensembl Gene ENSG00000115828
Encoded Proteins
IDBP-45694
glutaminyl-peptide cyclotransferase
IDBP-294038
glutaminyl-peptide cyclotransferase
IDBP-372722
glutaminyl-peptide cyclotransferase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes human pituitary glutaminyl cyclase, which is responsible for the presence of pyroglutamyl residues in many neuroendocrine peptides. The amino acid sequence of this enzyme is 86% identical to that of bovine glutaminyl cyclase. [provided by RefSeq, Jul 2008]
This gene encodes human pituitary glutaminyl cyclase, which is responsible for the presence of pyroglutamyl residues in many neuroendocrine peptides. The amino acid sequence of this enzyme is 86%% identical to that of bovine glutaminyl cyclase. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:37344574-37373322
Strand Forward strand
Band p22.2
Transcripts
ENST00000338415 ENSP00000344829
ENST00000404976 ENSP00000385391
ENST00000444022 ENSP00000389227
ENST00000470075
ENST00000480050
ENST00000469098
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
Experimentally validated
Total 13 [view]
Protein-Protein 12 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0008233 peptidase activity
GO:0008270 zinc ion binding
GO:0016603 glutaminyl-peptide cyclotransferase activity
Biological Process
GO:0006464 cellular protein modification process
GO:0006508 proteolysis
GO:0017186 peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase
Cellular Component
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000024084
View Gene Order
ENSBTAG00000013923
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.592583 Hs.79033
RefSeq NM_012413
HUGO
OMIM
CCDS CCDS1790
HPRD 06140
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca