Version 5.4
Homo sapiens Protein: CDC42EP3
Summary
InnateDB Protein IDBP-45804.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CDC42EP3
Protein Name CDC42 effector protein (Rho GTPase binding) 3
Synonyms BORG2; CEP3; UB1;
Species Homo sapiens
Ensembl Protein ENSP00000295324
InnateDB Gene IDBG-45802 (CDC42EP3)
Protein Structure
UniProt Annotation
Function Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation in fibroblasts. {ECO:0000269PubMed:10490598, ECO:0000269PubMed:11035016}.
Subcellular Localization Endomembrane system {ECO:0000269PubMed:11035016}; Peripheral membrane protein {ECO:0000269PubMed:11035016}. Cytoplasm, cytoskeleton {ECO:0000269PubMed:11035016}.
Disease Associations
Tissue Specificity Highly expressed in the heart and weakly in the brain. {ECO:0000269PubMed:10490598}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
Experimentally validated
Total 13 [view]
Protein-Protein 12 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0005519 cytoskeletal regulatory protein binding
Biological Process
GO:0007165 signal transduction
GO:0008360 regulation of cell shape
Cellular Component
GO:0005737 cytoplasm
GO:0012505 endomembrane system
GO:0015629 actin cytoskeleton
GO:0016020 membrane
Protein Structure and Domains
PDB ID
InterPro IPR000095 CRIB domain
PFAM PF00786
PRINTS
PIRSF
SMART SM00285
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9UKI2
PhosphoSite PhosphoSite-Q9UKI2
TrEMBL C9JEZ4
UniProt Splice Variant
Entrez Gene 10602
UniGene Hs.743363
RefSeq NP_006440
HUGO HGNC:16943
OMIM 606133
CCDS CCDS1791
HPRD 09364
IMGT
EMBL AC006369 AF094521 AF104857 AF164118 AK313483 AL136842 BC019270 BT007190 CH471053
GenPept AAC71773 AAD16888 AAD48815 AAH19270 AAP35854 AAX93072 BAG36267 CAB66776 EAX00390

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca