InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: APLP1

Summary

InnateDB Protein

IDBP-45877.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

APLP1

Protein Name

amyloid beta (A4) precursor-like protein 1

Synonyms

APLP;

Species

Homo sapiens

Ensembl Protein

ENSP00000221891

InnateDB Gene

IDBG-45875 (APLP1)

Protein Structure

UniProt Annotation

Function

May play a role in postsynaptic function. The C-terminal gamma-secretase processed fragment, ALID1, activates transcription activation through APBB1 (Fe65) binding (By similarity). Couples to JIP signal transduction through C-terminal binding. May interact with cellular G-protein signaling pathways. Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I. {ECO:0000250}.The gamma-CTF peptide, C30, is a potent enhancer of neuronal apoptosis. {ECO:0000250}.

Subcellular Localization

Cell membrane; Single-pass type I membrane protein.C30: Cytoplasm. Note=C-terminally processed in the Golgi complex.

Disease Associations

Tissue Specificity

Expressed in the cerebral cortex where it is localized to the postsynaptic density (PSD). {ECO:0000269PubMed:7494461}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 70 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	70 [view]
Protein-Protein	70 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008201	heparin binding
GO:0031694	alpha-2A adrenergic receptor binding
GO:0031695	alpha-2B adrenergic receptor binding
GO:0031696	alpha-2C adrenergic receptor binding
GO:0042802	identical protein binding
GO:0046914	transition metal ion binding

Biological Process

GO:0006378	mRNA polyadenylation
GO:0006417	regulation of translation
GO:0006897	endocytosis
GO:0006915	apoptotic process
GO:0007155	cell adhesion
GO:0007193	adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
GO:0007399	nervous system development
GO:0009887	organ morphogenesis
GO:0030198	extracellular matrix organization
GO:0030818	negative regulation of cAMP biosynthetic process
GO:0030900	forebrain development
GO:0071874	cellular response to norepinephrine stimulus

Cellular Component

GO:0005604	basement membrane
GO:0005794	Golgi apparatus
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0048471	perinuclear region of cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR008154 Amyloidogenic glycoprotein, extracellular
IPR008155 Amyloidogenic glycoprotein
IPR011178 Amyloidogenic glycoprotein, copper-binding
IPR015849 Amyloidogenic glycoprotein, heparin-binding
IPR019543 Beta-amyloid precursor protein C-terminal
IPR024329 Amyloidogenic glycoprotein, E2 domain

PFAM

PF12924
PF02177
PF10515
PF12925

PRINTS

PR00203

PIRSF

SMART

SM00006

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt