InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: IL26

Summary

InnateDB Protein

IDBP-46011.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IL26

Protein Name

interleukin 26

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000229134

InnateDB Gene

IDBG-46009 (IL26)

Protein Structure

UniProt Annotation

Function

May play a role in local mechanisms of mucosal immunity and seems to have a proinflammatory function. May play a role in inflammatory bowel disease. Activates STAT1 and STAT3, MAPK1/3 (ERK1/2), JUN and AKT. Induces expression of SOCS3, TNF-alpha and IL-8, secretion of IL-8 and IL-10 and surface expression of ICAM1. Decreases proliferation of intestinal epithelial cells. Is inhibited by heparin. {ECO:0000269PubMed:14764663, ECO:0000269PubMed:15178681, ECO:0000269PubMed:18483078}.

Subcellular Localization

Secreted {ECO:0000269PubMed:18483078}.

Disease Associations

Tissue Specificity

Expressed in HVS transformed T-cells but not other T-cell lines or primary stimulated T-cells. Expressed in colonic T-cells including Th17 inflammatory T-cells; the expression is significantly increased in serum of patients with Crohn's disease (at protein level). {ECO:0000269PubMed:18483078}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005125	cytokine activity

Biological Process

GO:0007267	cell-cell signaling
GO:0032874	positive regulation of stress-activated MAPK cascade
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046427	positive regulation of JAK-STAT cascade
GO:0050680	negative regulation of epithelial cell proliferation
GO:0050715	positive regulation of cytokine secretion
GO:0051897	positive regulation of protein kinase B signaling
GO:0070374	positive regulation of ERK1 and ERK2 cascade