InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TYROBP

Summary

InnateDB Protein

IDBP-46037.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TYROBP

Protein Name

TYRO protein tyrosine kinase binding protein

Synonyms

DAP12; KARAP; PLOSL;

Species

Homo sapiens

Ensembl Protein

ENSP00000262629

InnateDB Gene

IDBG-46035 (TYROBP)

Protein Structure

UniProt Annotation

Function

Non-covalently associates with activating receptors of the CD300 family. Cross-linking of CD300-TYROBP complexes results in cellular activation. Involved for instance in neutrophil activation mediated by integrin.

Subcellular Localization

Membrane; Single-pass type I membrane protein.

Disease Associations

Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL) [MIM:221770]: Recessively inherited disease characterized by a combination of psychotic symptoms rapidly progressing to presenile dementia and bone cysts restricted to wrists and ankles. PLOSL has a global distribution, although most of the patients have been diagnosed in Finland and Japan, with an estimated population prevalence of 2x10(-6) in the Finns. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Expressed at low levels in the early development of the hematopoietic system and in the promonocytic stage and at high levels in mature monocytes. Expressed in hematological cells and tissues such as peripheral blood leukocytes and spleen. Also found in bone marrow, lymph nodes, placenta, lung and liver. Expressed at lower levels in different parts of the brain especially in the basal ganglia and corpus callosum. {ECO:0000269PubMed:11922939}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	17 [view]
Protein-Protein	16 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005057	receptor signaling protein activity
GO:0005102	receptor binding
GO:0005515	protein binding
GO:0042802	identical protein binding

Biological Process

GO:0002281	macrophage activation involved in immune response
GO:0002283	neutrophil activation involved in immune response
GO:0006968	cellular defense response
GO:0007165	signal transduction
GO:0007229	integrin-mediated signaling pathway
GO:0007411	axon guidance
GO:0035556	intracellular signal transduction
GO:0045087	innate immune response
GO:0050776	regulation of immune response
GO:2001204	regulation of osteoclast development