InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: TYROBP

Summary

InnateDB Gene

IDBG-46035.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TYROBP

Gene Name

TYRO protein tyrosine kinase binding protein

Synonyms

DAP12; KARAP; PLOSL

Species

Homo sapiens

Ensembl Gene

ENSG00000011600

Encoded Proteins

IDBP-46037

TYRO protein tyrosine kinase binding protein

IDBP-378502

TYRO protein tyrosine kinase binding protein

IDBP-593072

TYRO protein tyrosine kinase binding protein

IDBP-765088

IDBP-765538

IDBP-765815

IDBP-760254

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 25402298

[Mus musculus] Tyrobp impairs host defence during pneumococcal pneumonia at the primary site of infection by inhibiting phagocytosis by alveolar macrophages.

Entrez Gene

Summary

This gene encodes a transmembrane signaling polypeptide which contains an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain. The encoded protein may associate with the killer-cell inhibitory receptor (KIR) family of membrane glycoproteins and may act as an activating signal transduction element. This protein may bind zeta-chain (TCR) associated protein kinase 70kDa (ZAP-70) and spleen tyrosine kinase (SYK) and play a role in signal transduction, bone modeling, brain myelination, and inflammation. Mutations within this gene have been associated with polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL), also known as Nasu-Hakola disease. Its putative receptor, triggering receptor expressed on myeloid cells 2 (TREM2), also causes PLOSL. Multiple alternative transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Mar 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:35904401-35908295

Strand

Reverse strand

Band

q13.12

Transcripts

ENST00000262629	ENSP00000262629
ENST00000424586	ENSP00000402371
ENST00000544690	ENSP00000445332
ENST00000586946	ENSP00000465656
ENST00000585901	ENSP00000468608
ENST00000588439
ENST00000589517	ENSP00000468447
ENST00000585626
ENST00000587837	ENSP00000465081

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	17 [view]
Protein-Protein	16 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005057	receptor signaling protein activity
GO:0005102	receptor binding
GO:0005515	protein binding
GO:0042802	identical protein binding

Biological Process

GO:0002281	macrophage activation involved in immune response
GO:0002283	neutrophil activation involved in immune response
GO:0006968	cellular defense response
GO:0007165	signal transduction
GO:0007229	integrin-mediated signaling pathway
GO:0007411	axon guidance
GO:0035556	intracellular signal transduction
GO:0045087	innate immune response
GO:0050776	regulation of immune response
GO:2001204	regulation of osteoclast development