InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SPOCK1

Summary

InnateDB Protein

IDBP-46105.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SPOCK1

Protein Name

sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1

Synonyms

SPOCK; TESTICAN; TIC1;

Species

Homo sapiens

Ensembl Protein

ENSP00000282223

InnateDB Gene

IDBG-46103 (SPOCK1)

Protein Structure

UniProt Annotation

Function

May play a role in cell-cell and cell-matrix interactions. May contribute to various neuronal mechanisms in the central nervous system.

Subcellular Localization

Secreted, extracellular space, extracellular matrix.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004867	serine-type endopeptidase inhibitor activity
GO:0004869	cysteine-type endopeptidase inhibitor activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0008191	metalloendopeptidase inhibitor activity

Biological Process

GO:0001558	regulation of cell growth
GO:0001764	neuron migration
GO:0007155	cell adhesion
GO:0007165	signal transduction
GO:0007399	nervous system development
GO:0010812	negative regulation of cell-substrate adhesion
GO:0010951	negative regulation of endopeptidase activity
GO:0010977	negative regulation of neuron projection development
GO:0021953	central nervous system neuron differentiation
GO:0022008	neurogenesis

Cellular Component

GO:0005578	proteinaceous extracellular matrix
GO:0005615	extracellular space
GO:0005737	cytoplasm
GO:0014069	postsynaptic density
GO:0016528	sarcoplasm
GO:0031594	neuromuscular junction
GO:0033268	node of Ranvier