InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RAP1B

Summary

InnateDB Protein

IDBP-46142.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RAP1B

Protein Name

RAP1B, member of RAS oncogene family

Synonyms

K-REV; RAL1B;

Species

Homo sapiens

Ensembl Protein

ENSP00000250559

InnateDB Gene

IDBG-46140 (RAP1B)

Protein Structure

UniProt Annotation

Function

GTP-binding protein that possesses intrinsic GTPase activity. Contributes to the polarizing activity of KRIT1 and CDH5 in the establishment and maintenance of correct endothelial cell polarity and vascular lumen. Required for the localization of phosphorylated PRKCZ, PARD3 and TIAM1 to the cell junction. Plays a role in the establishment of basal endothelial barrier function. {ECO:0000269PubMed:18660803, ECO:0000269PubMed:20332120, ECO:0000269PubMed:21840392}.

Subcellular Localization

Cell membrane. Cytoplasm, cytosol. Cell junction. Note=May shuttle between plasma membrane and cytosol. Presence of KRIT1 and CDH5 is required for its localization to the cell junction.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 60 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	60 [view]
Protein-Protein	60 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003924	GTPase activity
GO:0005515	protein binding
GO:0005525	GTP binding
GO:0019003	GDP binding
GO:0032403	protein complex binding

Biological Process

GO:0006112	energy reserve metabolic process
GO:0006184	GTP catabolic process
GO:0006886	intracellular protein transport
GO:0006913	nucleocytoplasmic transport
GO:0007165	signal transduction
GO:0007264	small GTPase mediated signal transduction
GO:0007596	blood coagulation
GO:0008283	cell proliferation
GO:0015031	protein transport
GO:0030168	platelet activation
GO:0032486	Rap protein signal transduction
GO:0044281	small molecule metabolic process
GO:0045955	negative regulation of calcium ion-dependent exocytosis
GO:0050796	regulation of insulin secretion
GO:0061028	establishment of endothelial barrier
GO:0070374	positive regulation of ERK1 and ERK2 cascade
GO:0071320	cellular response to cAMP
GO:1901888	regulation of cell junction assembly
GO:2000114	regulation of establishment of cell polarity
GO:2000301	negative regulation of synaptic vesicle exocytosis

Cellular Component

GO:0005622	intracellular
GO:0005811	lipid particle
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0005911	cell-cell junction
GO:0016020	membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000795 Elongation factor, GTP-binding domain
IPR001806 Small GTPase superfamily
IPR002041 Ran GTPase
IPR003578 Small GTPase superfamily, Rho type
IPR003579 Small GTPase superfamily, Rab type
IPR005225 Small GTP-binding protein domain
IPR006689 Small GTPase superfamily, ARF/SAR type
IPR013684 Mitochondrial Rho-like
IPR020849 Small GTPase superfamily, Ras type
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00009
PF00071
PF00025
PF08477

PRINTS

PR00315
PR00449
PR00627
PR00328

PIRSF

SMART

SM00176
SM00174
SM00175
SM00173

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt