InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CLIP3

Summary

InnateDB Protein

IDBP-46198.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CLIP3

Protein Name

CAP-GLY domain containing linker protein 3

Synonyms

CLIPR-59; CLIPR59; RSNL1;

Species

Homo sapiens

Ensembl Protein

ENSP00000353732

InnateDB Gene

IDBG-46196 (CLIP3)

Protein Structure

UniProt Annotation

Function

Functions as a cytoplasmic linker protein. Involved in TGN-endosome dynamics. May modulate the cellular compartmentalization of AKT kinase family and promote its cell membrane localization, thereby playing a role in glucose transport in adipocytes. {ECO:0000269PubMed:19139280}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:24001771}; Lipid-anchor {ECO:0000269PubMed:24001771}. Cytoplasm {ECO:0000269PubMed:24001771}. Golgi apparatus, Golgi stack {ECO:0000269PubMed:24001771}. Note=Localized to Golgi stacks as well as on tubulovesicular elements juxtaposed to Golgi cisternae.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	15 [view]
Protein-Protein	13 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	2 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008017	microtubule binding
GO:0035594	ganglioside binding

Biological Process

GO:0001934	positive regulation of protein phosphorylation
GO:0010828	positive regulation of glucose transport
GO:0018230	peptidyl-L-cysteine S-palmitoylation
GO:0031115	negative regulation of microtubule polymerization
GO:0043065	positive regulation of apoptotic process
GO:0044091	membrane biogenesis
GO:0045444	fat cell differentiation
GO:0045807	positive regulation of endocytosis
GO:0072321	chaperone-mediated protein transport
GO:0090004	positive regulation of establishment of protein localization to plasma membrane

Cellular Component

GO:0005795	Golgi stack
GO:0005802	trans-Golgi network
GO:0005886	plasma membrane
GO:0031901	early endosome membrane
GO:0032588	trans-Golgi network membrane
GO:0045121	membrane raft
GO:0055038	recycling endosome membrane