Version 5.4
Homo sapiens Gene: CLIP3
Summary
InnateDB Gene IDBG-46196.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CLIP3
Gene Name CAP-GLY domain containing linker protein 3
Synonyms CLIPR-59; CLIPR59; RSNL1
Species Homo sapiens
Ensembl Gene ENSG00000105270
Encoded Proteins
IDBP-46198
CAP-GLY domain containing linker protein 3
IDBP-763697
IDBP-762512
IDBP-765089
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the cytoplasmic linker protein 170 family. Members of this protein family contain a cytoskeleton-associated protein glycine-rich domain and mediate the interaction of microtubules with cellular organelles. The encoded protein plays a role in T cell apoptosis by facilitating the association of tubulin and the lipid raft ganglioside GD3. The encoded protein also functions as a scaffold protein mediating membrane localization of phosphorylated protein kinase B. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:36014660-36033343
Strand Reverse strand
Band q13.12
Transcripts
ENST00000360535 ENSP00000353732
ENST00000586457
ENST00000593074 ENSP00000466832
ENST00000592017 ENSP00000468689
ENST00000590559 ENSP00000466026
ENST00000585466
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 15 [view]
Protein-Protein 13 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 2 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008017 microtubule binding
GO:0035594 ganglioside binding
Biological Process
GO:0001934 positive regulation of protein phosphorylation
GO:0010828 positive regulation of glucose transport
GO:0018230 peptidyl-L-cysteine S-palmitoylation
GO:0031115 negative regulation of microtubule polymerization
GO:0043065 positive regulation of apoptotic process
GO:0044091 membrane biogenesis
GO:0045444 fat cell differentiation
GO:0045807 positive regulation of endocytosis
GO:0072321 chaperone-mediated protein transport
GO:0090004 positive regulation of establishment of protein localization to plasma membrane
Cellular Component
GO:0005795 Golgi stack
GO:0005802 trans-Golgi network
GO:0005886 plasma membrane
GO:0031901 early endosome membrane
GO:0032588 trans-Golgi network membrane
GO:0045121 membrane raft
GO:0055038 recycling endosome membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000013921
View Gene Order
ENSBTAG00000019674
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.466539
RefSeq NM_001199570 NM_015526
HUGO
OMIM
CCDS CCDS12486
HPRD 09572
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca