InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CYBA

Summary

InnateDB Protein

IDBP-46336.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CYBA

Protein Name

cytochrome b-245, alpha polypeptide

Synonyms

p22-PHOX;

Species

Homo sapiens

Ensembl Protein

ENSP00000261623

InnateDB Gene

IDBG-46334 (CYBA)

Protein Structure

UniProt Annotation

Function

Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide. {ECO:0000269PubMed:15824103}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:15585859, ECO:0000269PubMed:22808130}.

Disease Associations

Granulomatous disease, chronic, cytochrome-b-negative, autosomal recessive (ARCGD) [MIM:233690]: A disorder characterized by the inability of neutrophils and phagocytes to kill microbes that they have ingested. Patients suffer from life-threatening bacterial/fungal infections. {ECO:0000269PubMed:10759707, ECO:0000269PubMed:10910929, ECO:0000269PubMed:10914676, ECO:0000269PubMed:1415254, ECO:0000269PubMed:1763037, ECO:0000269PubMed:18422995, ECO:0000269PubMed:2243141, ECO:0000269PubMed:8168815}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 31 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	31 [view]
Protein-Protein	29 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0009055	electron carrier activity
GO:0016175	superoxide-generating NADPH oxidase activity
GO:0017124	SH3 domain binding
GO:0020037	heme binding
GO:0046872	metal ion binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0001938	positive regulation of endothelial cell proliferation
GO:0002474	antigen processing and presentation of peptide antigen via MHC class I
GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
GO:0003106	negative regulation of glomerular filtration by angiotensin
GO:0006801	superoxide metabolic process
GO:0006954	inflammatory response
GO:0008217	regulation of blood pressure
GO:0014895	smooth muscle hypertrophy
GO:0017004	cytochrome complex assembly
GO:0030307	positive regulation of cell growth
GO:0031667	response to nutrient levels
GO:0042493	response to drug
GO:0042554	superoxide anion generation
GO:0042590	antigen processing and presentation of exogenous peptide antigen via MHC class I
GO:0045087	innate immune response (InnateDB)
GO:0045730	respiratory burst
GO:0050665	hydrogen peroxide biosynthetic process
GO:0051701	interaction with host
GO:0055114	oxidation-reduction process
GO:0070555	response to interleukin-1
GO:0071230	cellular response to amino acid stimulus
GO:0071260	cellular response to mechanical stimulus
GO:0071310	cellular response to organic substance
GO:0071333	cellular response to glucose stimulus
GO:0071356	cellular response to tumor necrosis factor
GO:0071407	cellular response to organic cyclic compound
GO:0071480	cellular response to gamma radiation
GO:0090382	phagosome maturation

Cellular Component

GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005794	Golgi apparatus
GO:0016020	membrane
GO:0016324	apical plasma membrane
GO:0030141	secretory granule
GO:0030425	dendrite
GO:0030670	phagocytic vesicle membrane
GO:0043020	NADPH oxidase complex
GO:0043025	neuronal cell body
GO:0097038	perinuclear endoplasmic reticulum