InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CYBA

Summary

InnateDB Gene

IDBG-46334.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CYBA

Gene Name

cytochrome b-245, alpha polypeptide

Synonyms

p22-PHOX

Species

Homo sapiens

Ensembl Gene

ENSG00000051523

Encoded Proteins

IDBP-46336

cytochrome b-245, alpha polypeptide

IDBP-753225

IDBP-751171

IDBP-746735

IDBP-746525

IDBP-746601

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 20142487

CYBA is an NADPH oxidase and CYBA-dependent reactive oxygen species (ROS) are key regulators of neutrophil chemotactic migration.

Entrez Gene

Summary

Cytochrome b is comprised of a light chain (alpha) and a heavy chain (beta). This gene encodes the light, alpha subunit which has been proposed as a primary component of the microbicidal oxidase system of phagocytes. Mutations in this gene are associated with autosomal recessive chronic granulomatous disease (CGD), that is characterized by the failure of activated phagocytes to generate superoxide, which is important for the microbicidal activity of these cells. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 16:88643283-88651152

Strand

Reverse strand

Band

q24.2

Transcripts

ENST00000261623	ENSP00000261623
ENST00000567174	ENSP00000454951
ENST00000565588	ENSP00000455537
ENST00000562209
ENST00000566229	ENSP00000457060
ENST00000561972
ENST00000569359	ENSP00000456079
ENST00000566534
ENST00000568278	ENSP00000455506
ENST00000563526

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 31 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	31 [view]
Protein-Protein	29 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0009055	electron carrier activity
GO:0016175	superoxide-generating NADPH oxidase activity
GO:0017124	SH3 domain binding
GO:0020037	heme binding
GO:0046872	metal ion binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0001938	positive regulation of endothelial cell proliferation
GO:0002474	antigen processing and presentation of peptide antigen via MHC class I
GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
GO:0003106	negative regulation of glomerular filtration by angiotensin
GO:0006801	superoxide metabolic process
GO:0006954	inflammatory response
GO:0008217	regulation of blood pressure
GO:0014895	smooth muscle hypertrophy
GO:0017004	cytochrome complex assembly
GO:0030307	positive regulation of cell growth
GO:0031667	response to nutrient levels
GO:0042493	response to drug
GO:0042554	superoxide anion generation
GO:0042590	antigen processing and presentation of exogenous peptide antigen via MHC class I
GO:0045087	innate immune response (InnateDB)
GO:0045730	respiratory burst
GO:0050665	hydrogen peroxide biosynthetic process
GO:0051701	interaction with host
GO:0055114	oxidation-reduction process
GO:0070555	response to interleukin-1
GO:0071230	cellular response to amino acid stimulus
GO:0071260	cellular response to mechanical stimulus
GO:0071310	cellular response to organic substance
GO:0071333	cellular response to glucose stimulus
GO:0071356	cellular response to tumor necrosis factor
GO:0071407	cellular response to organic cyclic compound
GO:0071480	cellular response to gamma radiation
GO:0090382	phagosome maturation

Cellular Component

GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005794	Golgi apparatus
GO:0016020	membrane
GO:0016324	apical plasma membrane
GO:0030141	secretory granule
GO:0030425	dendrite
GO:0030670	phagocytic vesicle membrane
GO:0043020	NADPH oxidase complex
GO:0043025	neuronal cell body
GO:0097038	perinuclear endoplasmic reticulum