InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: P2RX3

Summary

InnateDB Protein

IDBP-46466.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

P2RX3

Protein Name

purinergic receptor P2X, ligand-gated ion channel, 3

Synonyms

P2X3;

Species

Homo sapiens

Ensembl Protein

ENSP00000263314

InnateDB Gene

IDBG-46464 (P2RX3)

Protein Structure

UniProt Annotation

Function

Receptor for ATP that acts as a ligand-gated ion channel.

Subcellular Localization

Membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001614	purinergic nucleotide receptor activity
GO:0004931	extracellular ATP-gated cation channel activity
GO:0005216	ion channel activity
GO:0005524	ATP binding

Biological Process

GO:0001666	response to hypoxia
GO:0006810	transport
GO:0006811	ion transport
GO:0006812	cation transport
GO:0007165	signal transduction
GO:0007268	synaptic transmission
GO:0007274	neuromuscular synaptic transmission
GO:0009266	response to temperature stimulus
GO:0009408	response to heat
GO:0009409	response to cold
GO:0009612	response to mechanical stimulus
GO:0009743	response to carbohydrate
GO:0010033	response to organic substance
GO:0010524	positive regulation of calcium ion transport into cytosol
GO:0014832	urinary bladder smooth muscle contraction
GO:0019228	neuronal action potential
GO:0030432	peristalsis
GO:0033198	response to ATP
GO:0034220	ion transmembrane transport
GO:0035590	purinergic nucleotide receptor signaling pathway
GO:0048167	regulation of synaptic plasticity
GO:0048266	behavioral response to pain
GO:0050850	positive regulation of calcium-mediated signaling
GO:0050909	sensory perception of taste
GO:0051260	protein homooligomerization

Cellular Component

GO:0005639	integral component of nuclear inner membrane
GO:0005791	rough endoplasmic reticulum
GO:0005794	Golgi apparatus
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0030424	axon
GO:0043005	neuron projection
GO:0043025	neuronal cell body
GO:0043195	terminal bouton
GO:0043197	dendritic spine
GO:0043235	receptor complex
GO:0045121	membrane raft