InnateDB Protein
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IDBP-46579.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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MINA
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Protein Name
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MYC induced nuclear antigen
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000328251
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InnateDB Gene
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IDBG-46577 (MINA)
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Protein Structure
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Function |
Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Is involved in the demethylation of trimethylated 'Lys-9' on histone H3 (H3K9me3), leading to an increase in ribosomal RNA expression. Also catalyzes the hydroxylation of 60S ribosomal protein L27a on 'His-39'. May play an important role in cell growth and survival. May be involved in ribosome biogenesis, most likely during the assembly process of pre-ribosomal particles. {ECO:0000269PubMed:12091391, ECO:0000269PubMed:14695334, ECO:0000269PubMed:15534111, ECO:0000269PubMed:15819408, ECO:0000269PubMed:15897898, ECO:0000269PubMed:17317935, ECO:0000269PubMed:19502796, ECO:0000269PubMed:23103944}.
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Subcellular Localization |
Nucleus {ECO:0000269PubMed:12091391, ECO:0000269PubMed:15819408}. Nucleus, nucleolus {ECO:0000269PubMed:12091391, ECO:0000269PubMed:15819408}.
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Disease Associations |
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Tissue Specificity |
Expressed in liver, skeletal muscle, heart, pancreas, and placenta. Not detected in brain, lung or kidney. Expressed in several lung cancer tissues, but is barely detected in the adjacent non-cancerous tissues. Also highly expressed in several esophageal squamous cell carcinoma (ESCC), and colon cancer tissues, and in various cancer cell lines. {ECO:0000269PubMed:14695334, ECO:0000269PubMed:15534111, ECO:0000269PubMed:15897898, ECO:0000269PubMed:19502796}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
9
[view]
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Protein-Protein |
8
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
Accession |
GO Term |
GO:0001191
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RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription
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GO:0046872
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metal ion binding
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GO:0051213
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dioxygenase activity
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR003347
JmjC domain
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PFAM |
PF02373
PF08007
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PRINTS |
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PIRSF |
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SMART |
SM00558
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TIGRFAMs |
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Modification |
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SwissProt |
Q8IUF8
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PhosphoSite |
PhosphoSite-Q8IUF8
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TrEMBL |
D6RCB6
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UniProt Splice Variant |
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Entrez Gene |
84864
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UniGene |
Hs.742206
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RefSeq |
NP_001035998
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HUGO |
HGNC:19441
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OMIM |
612049
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CCDS |
CCDS43114
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HPRD |
17575
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IMGT |
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EMBL |
AB083189
AB083190
AB083191
AB083192
AB083193
AC026100
AC110491
AK027299
AY302110
AY390536
AY456380
BC014928
CH471052
CR627479
DQ453796
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GenPept |
AAH14928
AAP59421
AAR21572
AAR27293
ABE28016
BAB55024
BAC16358
BAC16359
BAC16360
BAC16361
BAC16537
CAH10679
EAW79872
EAW79873
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