Version 5.4
Homo sapiens Protein: ARHGEF5
Summary
InnateDB Protein IDBP-46620.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ARHGEF5
Protein Name Rho guanine nucleotide exchange factor (GEF) 5
Synonyms GEF5; P60; TIM; TIM1;
Species Homo sapiens
Ensembl Protein ENSP00000056217
InnateDB Gene IDBG-46618 (ARHGEF5)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity Mainly expressed in kidney, liver, pancreas, lung and placenta.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
Experimentally validated
Total 20 [view]
Protein-Protein 19 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005089 Rho guanyl-nucleotide exchange factor activity
GO:0005515 protein binding
GO:0005525 GTP binding
Biological Process
GO:0002408 myeloid dendritic cell chemotaxis
GO:0030036 actin cytoskeleton organization
GO:0032319 regulation of Rho GTPase activity
GO:0032321 positive regulation of Rho GTPase activity
GO:0035023 regulation of Rho protein signal transduction
GO:0035556 intracellular signal transduction
GO:0071803 positive regulation of podosome assembly
Cellular Component
Protein Structure and Domains
PDB ID
InterPro IPR000219 Dbl homology (DH) domain
IPR001452 SH3 domain
IPR001849 Pleckstrin homology domain
IPR011511 Variant SH3 domain
PFAM PF00621
PF00018
PF14604
PF00169
PF07653
PRINTS PR00452
PIRSF
SMART SM00325
SM00326
SM00233
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q12774
PhosphoSite PhosphoSite-Q12774
TrEMBL H9XFB6
UniProt Splice Variant
Entrez Gene 7984
UniGene Hs.624956
RefSeq NP_005426
HUGO HGNC:13209
OMIM 600888
CCDS CCDS34771
HPRD 02932
IMGT
EMBL AC004534 AK160365 BC010046 BC011839 BC014555 CH471146 JQ511948 U02082
GenPept AAA18010 AAC12958 AAH10046 AAH11839 AAH14555 AFG72982 BAD18708 EAW80096

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca