Version 5.4
Homo sapiens Protein: GSDMB
Summary
InnateDB Protein IDBP-46625.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GSDMB
Protein Name gasdermin B
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000312584
InnateDB Gene IDBG-46623 (GSDMB)
Protein Structure
UniProt Annotation
Function May play a role as secretory or metabolic product involved in secretory pathway. May also play a role in achieving and maintaining the final differentiation state of epithelial cells. {ECO:0000269PubMed:15010812, ECO:0000269PubMed:18038310}.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:18038310}. Note=Vesicular localization in the apical region of gastric chief cells and colonic surface mucous cells, and the basal region of neuroendocrine cells.
Disease Associations
Tissue Specificity Expressed in gastric, liver and colon cell lines, carcinomas and non-lesional tissues. {ECO:0000269PubMed:18038310}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated
Total 8 [view]
Protein-Protein 7 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0045087 innate immune response
Cellular Component
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR007677 Gasdermin
PFAM PF04598
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8TAX9
PhosphoSite PhosphoSite-Q8TAX9
TrEMBL
UniProt Splice Variant
Entrez Gene 55876
UniGene Hs.638861
RefSeq NP_001035936
HUGO HGNC:23690
OMIM 611221
CCDS CCDS42313
HPRD 17082
IMGT
EMBL AC090844 AF119884 AF258572 AK000409 AK296607 BC025682 BX538068 CH471152
GenPept AAF69638 AAG23775 AAH25682 BAA91146 BAG59219 CAD97998 EAW60614

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca