Version 5.4
Homo sapiens Protein: HELT
Summary
InnateDB Protein IDBP-46641.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HELT
Protein Name helt bHLH transcription factor
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000343464
InnateDB Gene IDBG-46639 (HELT)
Protein Structure
UniProt Annotation
Function Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGCG-3'. {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000255PROSITE- ProRule:PRU00380, ECO:0000255PROSITE-ProRule:PRU00981}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0046983 protein dimerization activity
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
Cellular Component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID
InterPro IPR003650 Orange
IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
PFAM PF07527
PF00010
PRINTS
PIRSF
SMART SM00353
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt A6NFD8
PhosphoSite PhosphoSite-NP_001025058
TrEMBL
UniProt Splice Variant
Entrez Gene 391723
UniGene Hs.531242
RefSeq NP_001025058
HUGO HGNC:33783
OMIM
CCDS
HPRD
IMGT
EMBL AC093824 BC140795 BC144569 CH471056
GenPept AAI40796 AAI44570 EAX04657

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca