InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: UBE2L6

Summary

InnateDB Protein

IDBP-46771.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

UBE2L6

Protein Name

ubiquitin-conjugating enzyme E2L 6

Synonyms

RIG-B; UBCH8;

Species

Homo sapiens

Ensembl Protein

ENSP00000287156

InnateDB Gene

IDBG-46767 (UBE2L6)

Protein Structure

UniProt Annotation

Function

Catalyzes the covalent attachment of ubiquitin or ISG15 to other proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Promotes ubiquitination and subsequent proteasomal degradation of FLT3. {ECO:0000269PubMed:15131269, ECO:0000269PubMed:16428300, ECO:0000269PubMed:20508617}.

Subcellular Localization

Disease Associations

Tissue Specificity

Present in natural killer cells (at protein level). {ECO:0000269PubMed:16709802}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 52 experimentally validated interaction(s) in this database.

Experimentally validated
Total	52 [view]
Protein-Protein	52 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0019787	small conjugating protein ligase activity
GO:0042296	ISG15 ligase activity

Biological Process

GO:0006464	cellular protein modification process
GO:0016567	protein ubiquitination
GO:0019221	cytokine-mediated signaling pathway
GO:0019941	modification-dependent protein catabolic process
GO:0032020	ISG15-protein conjugation
GO:0032480	negative regulation of type I interferon production
GO:0045087	innate immune response