InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: UBE2L6

Summary

InnateDB Gene

IDBG-46767.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

UBE2L6

Gene Name

ubiquitin-conjugating enzyme E2L 6

Synonyms

RIG-B; UBCH8

Species

Homo sapiens

Ensembl Gene

ENSG00000156587

Encoded Proteins

IDBP-46769

ubiquitin-conjugating enzyme E2L 6

IDBP-46771

ubiquitin-conjugating enzyme E2L 6

IDBP-586258

ubiquitin-conjugating enzyme E2L 6

IDBP-595668

ubiquitin-conjugating enzyme E2L 6

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein ligases (E3s). This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is highly similar in primary structure to the enzyme encoded by the UBE2L3 gene. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:57551656-57568284

Strand

Reverse strand

Band

q12.1

Transcripts

ENST00000340573	ENSP00000341980
ENST00000287156	ENSP00000287156
ENST00000528275
ENST00000527022	ENSP00000435265
ENST00000526659	ENSP00000434348

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 52 experimentally validated interaction(s) in this database.

Experimentally validated
Total	52 [view]
Protein-Protein	52 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0016881	acid-amino acid ligase activity
GO:0019787	small conjugating protein ligase activity
GO:0042296	ISG15 ligase activity

Biological Process

GO:0006464	cellular protein modification process
GO:0008152	metabolic process
GO:0016567	protein ubiquitination
GO:0019221	cytokine-mediated signaling pathway
GO:0019941	modification-dependent protein catabolic process
GO:0032020	ISG15-protein conjugation
GO:0032480	negative regulation of type I interferon production
GO:0045087	innate immune response