InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: RCL1

Summary

InnateDB Protein

IDBP-46798.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RCL1

Protein Name

RNA terminal phosphate cyclase-like 1

Synonyms

RNAC; RPCL1;

Species

Homo sapiens

Ensembl Protein

ENSP00000371169

InnateDB Gene

IDBG-46796 (RCL1)

Protein Structure

UniProt Annotation

Function

Does not have cyclase activity. Plays a role in 40S- ribosomal-subunit biogenesis in the early pre-rRNA processing steps at sites A0, A1 and A2 that are required for proper maturation of the 18S RNA (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus, nucleolus {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity

Biological Process

GO:0006396	RNA processing
GO:0008150	biological_process
GO:0042254	ribosome biogenesis

Cellular Component

GO:0005730

nucleolus

Protein Structure and Domains

PDB ID

InterPro

IPR000228 RNA 3\'-terminal phosphate cyclase
IPR013791 RNA 3\'-terminal phosphate cyclase, insert domain
IPR013792 RNA 3\'-terminal phosphate cyclase/enolpyruvate transferase, alpha/beta
IPR016443 RNA 3\'-terminal phosphate cyclase type 2
IPR023797 RNA 3\'-terminal phosphate cyclase domain

PFAM

PF05189
PF01137

PRINTS

PIRSF

PIRSF005378

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9Y2P8