InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ATRN

Summary

InnateDB Protein

IDBP-46870.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ATRN

Protein Name

attractin

Synonyms

DPPT-L; MGCA;

Species

Homo sapiens

Ensembl Protein

ENSP00000262919

InnateDB Gene

IDBG-46868 (ATRN)

Protein Structure

UniProt Annotation

Function

Involved in the initial immune cell clustering during inflammatory response and may regulate chemotactic activity of chemokines. May play a role in melanocortin signaling pathways that regulate energy homeostasis and hair color. Low-affinity receptor for agouti (By similarity). Has a critical role in normal myelination in the central nervous system (By similarity). {ECO:0000250}.

Subcellular Localization

Isoform 1: Cell membrane; Single-pass type I membrane protein.Isoform 2: Secreted.Isoform 3: Secreted.

Disease Associations

Tissue Specificity

Isoform 2 is detected in plasma (at protein level). Expressed and secreted by activated T-lymphocytes. Expressed at low to moderate levels in peripheral blood leukocytes, spleen, lymph node, tonsil, bone marrow and fetal liver. At very low levels found in thymus. Isoform 2 is the major isoform in peripheral blood leukocytes. {ECO:0000269PubMed:10811918, ECO:0000269PubMed:17261078}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004872	receptor activity
GO:0005515	protein binding
GO:0030246	carbohydrate binding

Biological Process

GO:0006954	inflammatory response
GO:0006979	response to oxidative stress
GO:0007275	multicellular organismal development
GO:0021549	cerebellum development
GO:0040014	regulation of multicellular organism growth
GO:0042552	myelination
GO:0043473	pigmentation

Cellular Component

GO:0005615	extracellular space
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000742 Epidermal growth factor-like domain
IPR000859 CUB domain
IPR001304 C-type lectin
IPR002049 EGF-like, laminin
IPR002165 Plexin
IPR006652 Kelch repeat type 1
IPR016187 C-type lectin fold
IPR016201 Plexin-like fold

PFAM

PF00008
PF00431
PF00059
PF00053
PF01437
PF01344

PRINTS

PIRSF

SMART

SM00181
SM00042
SM00034
SM00180
SM00612
SM00423

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O75882