InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GFRA3

Summary

InnateDB Protein

IDBP-46883.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GFRA3

Protein Name

GDNF family receptor alpha 3

Synonyms

GDNFR3;

Species

Homo sapiens

Ensembl Protein

ENSP00000274721

InnateDB Gene

IDBG-46879 (GFRA3)

Protein Structure

UniProt Annotation

Function

Receptor for the glial cell line-derived neurotrophic factor, ARTN (artemin). Mediates the artemin-induced autophosphorylation and activation of the RET receptor tyrosine kinase. {ECO:0000269PubMed:9883723}.

Subcellular Localization

Cell membrane; Lipid-anchor, GPI-anchor.

Disease Associations

Tissue Specificity

Widely expressed in adult and fetus which exhibit a similar pattern. Essentially not expressed in the central nervous system, but highly expressed in several sensory and sympathetic ganglia of the peripheral nervous system. Moderate expression in many non-neuronal tissues, particularly those of the digestive and urogenital systems, but high expression in stomach and appendix. Several types of glandular tissues show low expression. Very low or no expression detected in the hematopoietic system. {ECO:0000269PubMed:9576965}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005515	protein binding
GO:0008046	axon guidance receptor activity

Biological Process

GO:0001764	neuron migration
GO:0007165	signal transduction
GO:0007399	nervous system development
GO:0007411	axon guidance
GO:0007422	peripheral nervous system development
GO:0048485	sympathetic nervous system development
GO:0048666	neuron development

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0009897	external side of plasma membrane
GO:0019898	extrinsic component of membrane
GO:0031225	anchored component of membrane
GO:0043231	intracellular membrane-bounded organelle

Protein Structure and Domains

PDB ID

InterPro

IPR003438 Glial cell line-derived neurotrophic factor receptor
IPR003505 Glial cell line-derived neurotrophic factor receptor, alpha 3
IPR016017 GDNF/GAS1

PFAM

PF02351

PRINTS

PR01316
PR01319

PIRSF

SMART

SM00907

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt