InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CSF3

Summary

InnateDB Protein

IDBP-46889.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CSF3

Protein Name

colony stimulating factor 3 (granulocyte)

Synonyms

C17orf33; CSF3OS; GCSF;

Species

Homo sapiens

Ensembl Protein

ENSP00000225474

InnateDB Gene

IDBG-46887 (CSF3)

Protein Structure

UniProt Annotation

Function

Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. This CSF induces granulocytes.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	1 [view]
Protein-DNA	5 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005125	cytokine activity
GO:0005130	granulocyte colony-stimulating factor receptor binding
GO:0008083	growth factor activity
GO:0019899	enzyme binding

Biological Process

GO:0006955	immune response
GO:0007275	multicellular organismal development
GO:0008284	positive regulation of cell proliferation
GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling
GO:0019221	cytokine-mediated signaling pathway
GO:0030838	positive regulation of actin filament polymerization
GO:0030851	granulocyte differentiation
GO:0032092	positive regulation of protein binding
GO:0033138	positive regulation of peptidyl-serine phosphorylation
GO:0042993	positive regulation of transcription factor import into nucleus
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation
GO:0051897	positive regulation of protein kinase B signaling
GO:0071222	cellular response to lipopolysaccharide
GO:0071345	cellular response to cytokine stimulus
GO:1901215	negative regulation of neuron death
GO:2000251	positive regulation of actin cytoskeleton reorganization