InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ZRSR2

Summary

InnateDB Protein

IDBP-46937.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ZRSR2

Protein Name

zinc finger (CCCH type), RNA-binding motif and serine/arginine rich 2

Synonyms

U2AF1-RS2; U2AF1L2; U2AF1RS2; URP;

Species

Homo sapiens

Ensembl Protein

ENSP00000303015

InnateDB Gene

IDBG-46935 (ZRSR2)

Protein Structure

UniProt Annotation

Function

Pre-mRNA-binding protein required for splicing of both U2- and U12-type introns. Selectively interacts with the 3'-splice site of U2- and U12-type pre-mRNAs and promotes different steps in U2 and U12 intron splicing. Recruited to U12 pre-mRNAs in an ATP- dependent manner and is required for assembly of the prespliceosome, a precursor to other spliceosomal complexes. For U2-type introns, it is selectively and specifically required for the second step of splicing. {ECO:0000269PubMed:21041408, ECO:0000269PubMed:9237760}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:15146077}.

Disease Associations

Tissue Specificity

Widely expressed. {ECO:0000269PubMed:9237760}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 41 experimentally validated interaction(s) in this database.

Experimentally validated
Total	41 [view]
Protein-Protein	41 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0005515	protein binding
GO:0030628	pre-mRNA 3'-splice site binding
GO:0046872	metal ion binding

Biological Process

GO:0000245	spliceosomal complex assembly
GO:0000398	mRNA splicing, via spliceosome
GO:0008380	RNA splicing

Cellular Component

GO:0005689

U12-type spliceosomal complex

Protein Structure and Domains

PDB ID

InterPro

IPR000504 RNA recognition motif domain
IPR000571 Zinc finger, CCCH-type
IPR003954 RNA recognition motif domain, eukaryote
IPR009145 U2 auxiliary factor small subunit

PFAM

PF00076
PF00642

PRINTS

PR01848

PIRSF

SMART

SM00360
SM00356
SM00361

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt