InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CBFA2T3

Summary

InnateDB Protein

IDBP-46978.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CBFA2T3

Protein Name

core-binding factor, runt domain, alpha subunit 2; translocated to, 3

Synonyms

ETO2; MTG16; MTGR2; ZMYND4;

Species

Homo sapiens

Ensembl Protein

ENSP00000268679

InnateDB Gene

IDBG-46976 (CBFA2T3)

Protein Structure

UniProt Annotation

Function

Functions as a transcriptional repressor. Regulates the proliferation and the differentiation of erythroid progenitors by repressing the expression of TAL1 target genes. Plays a role in granulocyte differentiation.Isoform 2 functions as an A-kinase-anchoring protein.

Subcellular Localization

Isoform 1: Nucleus, nucleolus. Note=The RUNX1-CBFA2T3 fusion protein localizes to the nucleoplasm.Isoform 2: Nucleus, nucleoplasm {ECO:0000269PubMed:11823486}. Golgi apparatus membrane {ECO:0000269PubMed:11823486}.

Disease Associations

Note=A chromosomal aberration involving CBFA2T3 is found in therapy-related myeloid malignancies. Translocation t(16;21)(q24;q22) that forms a RUNX1-CBFA2T3 fusion protein.

Tissue Specificity

Widely expressed with higher expression in heart, pancreas, skeletal muscle, spleen, thymus and peripheral blood leukocytes. Expressed in hematopoietic cells (at protein level). {ECO:0000269PubMed:15231665, ECO:0000269PubMed:9596646, ECO:0000269PubMed:9790752}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 33 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	33 [view]
Protein-Protein	33 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003682	chromatin binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0046872	metal ion binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0008283	cell proliferation
GO:0030851	granulocyte differentiation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter

Cellular Component

GO:0000139	Golgi membrane
GO:0005622	intracellular
GO:0005654	nucleoplasm
GO:0005730	nucleolus

Protein Structure and Domains

PDB ID

InterPro

IPR002893 Zinc finger, MYND-type
IPR003894 TAFH/NHR1
IPR013289 Eight-Twenty-One
IPR013292 Myeloid transforming gene on chromosome 16 (MTG16)
IPR014896 NHR2-like

PFAM

PF01753
PF07531
PF08788

PRINTS

PR01875
PR01878

PIRSF

SMART

SM00549

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt