InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CTNND1

Summary

InnateDB Protein

IDBP-47097.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CTNND1

Protein Name

catenin (cadherin-associated protein), delta 1

Synonyms

CAS; CTNND; p120; p120(CAS); p120(CTN); P120CAS; P120CTN;

Species

Homo sapiens

Ensembl Protein

ENSP00000354907

InnateDB Gene

IDBG-47085 (CTNND1)

Protein Structure

UniProt Annotation

Function

Binds to and inhibits the transcriptional repressor ZBTB33, which may lead to activation of target genes of the Wnt signaling pathway (By similarity). Associates with and regulates the cell adhesion properties of both C-, E- and N-cadherins, being critical for their surface stability. Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors. Promotes GLIS2 C-terminal cleavage. {ECO:0000250, ECO:0000269PubMed:17344476, ECO:0000269PubMed:20371349}.

Subcellular Localization

Cytoplasm. Nucleus. Cell membrane. Note=Interaction with GLIS2 promotes nuclear translocation (By similarity). Detected at cell-cell contacts. NANOS1 induces its translocation from sites of cell-cell contact to the cytoplasm. Isoforms 4A and 1AB are excluded from the nucleus. {ECO:0000250}.Isoform 1A: Nucleus.Isoform 2A: Nucleus.Isoform 3A: Nucleus.

Disease Associations

Tissue Specificity

Expressed in vascular endothelium. Melanocytes and melanoma cells primarily express the long isoform 1A, whereas keratinocytes express shorter isoforms, especially 3A. The shortest isoform 4A, is detected in normal keratinocytes and melanocytes, and generally lost from cells derived from squamous cell carcinomas or melanomas. The C-terminal alternatively spliced exon B is present in the p120ctn transcripts in the colon, intestine and prostate, but lost in several tumor tissues derived from these organs. {ECO:0000269PubMed:11896187, ECO:0000269PubMed:14699141}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 73 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.

Experimentally validated
Total	73 [view]
Protein-Protein	73 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	16 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005488	binding
GO:0005515	protein binding
GO:0045296	cadherin binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007155	cell adhesion
GO:0016055	Wnt signaling pathway
GO:0034329	cell junction assembly
GO:0034332	adherens junction organization
GO:0045216	cell-cell junction organization
GO:0090090	negative regulation of canonical Wnt signaling pathway

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0005911	cell-cell junction
GO:0030496	midbody
GO:0070062	extracellular vesicular exosome