Version 5.4
Homo sapiens Protein: GFRA4
Summary
InnateDB Protein IDBP-47228.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GFRA4
Protein Name GDNF family receptor alpha 4
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000313423
InnateDB Gene IDBG-47226 (GFRA4)
Protein Structure
UniProt Annotation
Function Receptor for persephin. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor. May be important in C-cell development and, in the postnatal development of the adrenal medulla.
Subcellular Localization Isoform GFRalpha4a: Cell membrane; Lipid- anchor, GPI-anchor.Isoform GFRalpha4b: Cell membrane; Lipid- anchor, GPI-anchor.Isoform GFRalpha4c: Secreted.
Disease Associations
Tissue Specificity Predominantly expressed in the adult thyroid gland. Low levels also found in fetal adrenal and thyroid glands.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0016167 glial cell-derived neurotrophic factor receptor activity
Biological Process
GO:0030279 negative regulation of ossification
GO:0035860 glial cell-derived neurotrophic factor receptor signaling pathway
Cellular Component
GO:0005615 extracellular space
GO:0005886 plasma membrane
GO:0031225 anchored component of membrane
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR003438 Glial cell line-derived neurotrophic factor receptor
IPR016017 GDNF/GAS1
PFAM PF02351
PRINTS PR01316
PIRSF
SMART SM00907
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9GZZ7
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 64096
UniGene
RefSeq NP_665705
HUGO HGNC:13821
OMIM
CCDS CCDS13056
HPRD 11003
IMGT
EMBL AF253318 AJ291673 AJ291674 AJ291675 AL356755
GenPept AAG25925 CAC16508 CAC19690 CAC19691 CAC19692 CAI23466

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca