Version 5.4
Homo sapiens Gene: GFRA4
Summary
InnateDB Gene IDBG-47226.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GFRA4
Gene Name GDNF family receptor alpha 4
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000125861
Encoded Proteins
IDBP-47228
GDNF family receptor alpha 4
IDBP-47230
GDNF family receptor alpha 4
IDBP-587205
GDNF family receptor alpha 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for persephin, and mediates activation of the RET tyrosine kinase receptor. This gene is a candidate gene for RET-associated diseases. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 20:3659292-3663399
Strand Reverse strand
Band p13
Transcripts
ENST00000319242 ENSP00000313423
ENST00000290417 ENSP00000290417
ENST00000477160 ENSP00000435801
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0016167 glial cell-derived neurotrophic factor receptor activity
Biological Process
GO:0030279 negative regulation of ossification
GO:0035860 glial cell-derived neurotrophic factor receptor signaling pathway
Cellular Component
GO:0005615 extracellular space
GO:0005886 plasma membrane
GO:0031225 anchored component of membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000027316
View Gene Order
ENSBTAG00000013160
Not yet available
Pathways
NETPATH
REACTOME
REACT_18312
NCAM1 interactions pathway
REACT_18334
NCAM signaling for neurite out-growth pathway
REACT_111045
Developmental Biology pathway
REACT_18266
Axon guidance pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt Q9GZZ7
TrEMBL
UniProt Splice Variant
Entrez Gene 64096
UniGene
RefSeq NM_022139 NM_145762 XM_005260793
HUGO HGNC:13821
OMIM
CCDS CCDS13055 CCDS13056
HPRD
IMGT
EMBL AF253318 AJ291673 AJ291674 AJ291675 AL356755
GenPept AAG25925 CAC16508 CAC19690 CAC19691 CAC19692 CAI23466
RNA Seq Atlas 64096

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca