InnateDB Protein
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IDBP-47319.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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WIPF2
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Protein Name
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WAS/WASL interacting protein family, member 2
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000320924
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InnateDB Gene
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IDBG-47317 (WIPF2)
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Protein Structure
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Function |
Plays an active role in the formation of cell surface protrusions downstream of activated PDGFB receptors. Plays an important role in actin-microspike formation through cooperation with WASL. May cooperate with WASP and WASL to induce mobilization and reorganization of the actin filament system. {ECO:0000269PubMed:11829459, ECO:0000269PubMed:12213210}.
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Subcellular Localization |
Cytoplasm, cytoskeleton {ECO:0000269PubMed:11829459, ECO:0000269PubMed:12213210}. Note=Localized to stress fibers and bundles of actin filaments.
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Disease Associations |
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Tissue Specificity |
Expressed mainly in brain, colon, lung and stomach (at protein level). Ubiquitously expressed, with high expression in brain, kidney, lung, and placenta. {ECO:0000269PubMed:11829459, ECO:0000269PubMed:12213210}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
19
[view]
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Protein-Protein |
19
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
GO:0038096
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Fc-gamma receptor signaling pathway involved in phagocytosis
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GO:0045087
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innate immune response
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Cellular Component |
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PDB ID |
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InterPro |
IPR003124
WH2 domain
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PFAM |
PF02205
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PRINTS |
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PIRSF |
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SMART |
SM00246
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TIGRFAMs |
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Modification |
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SwissProt |
Q8TF74
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PhosphoSite |
PhosphoSite-Q8TF74
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TrEMBL |
J3QKM5
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UniProt Splice Variant |
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Entrez Gene |
147179
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UniGene |
Hs.731598
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RefSeq |
NP_573571
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HUGO |
HGNC:30923
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OMIM |
609692
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CCDS |
CCDS11364
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HPRD |
18304
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IMGT |
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EMBL |
AB043786
AC068669
AC080112
AF370396
AJ431177
AK289578
AK289779
AK290301
AK315836
AL834239
BC065551
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GenPept |
AAH65551
AAQ15232
BAB85113
BAF82267
BAF82468
BAF82990
BAF98727
CAD24007
CAH56360
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