Version 5.4
Homo sapiens Gene: WIPF2
Summary
InnateDB Gene IDBG-47317.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol WIPF2
Gene Name WAS/WASL interacting protein family, member 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000171475
Encoded Proteins
IDBP-47319
WAS/WASL interacting protein family, member 2
IDBP-242285
WAS/WASL interacting protein family, member 2
IDBP-759457
IDBP-759943
IDBP-759893
IDBP-764582
IDBP-760251
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a WASP interacting protein (WIP)-related protein. It has been shown that this protein has a role in the WASP-mediated organization of the actin cytoskeleton and that this protein is a potential link between the activated platelet-derived growth factor receptor and the actin polymerization machinery. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:40219304-40284136
Strand Forward strand
Band q21.2
Transcripts
ENST00000323571 ENSP00000320924
ENST00000394103 ENSP00000377663
ENST00000494757
ENST00000584296 ENSP00000463149
ENST00000582781 ENSP00000463869
ENST00000583268 ENSP00000462386
ENST00000583130 ENSP00000462350
ENST00000578304
ENST00000585043 ENSP00000462826
ENST00000578623
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
Experimentally validated
Total 19 [view]
Protein-Protein 19 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005515 protein binding
Biological Process
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0045087 innate immune response
Cellular Component
GO:0005829 cytosol
GO:0005856 cytoskeleton
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000038013
View Gene Order
ENSBTAG00000038126
Not yet available
Pathways
NETPATH
REACTOME
REACT_160086
Regulation of actin dynamics for phagocytic cup formation pathway
REACT_6802
Innate Immune System pathway
REACT_6900
Immune System pathway
REACT_160123
Fcgamma receptor (FCGR) dependent phagocytosis pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.421622 Hs.705989 Hs.706215 Hs.731598
RefSeq NM_133264 XM_005257083 XM_005257084
HUGO
OMIM
CCDS CCDS11364
HPRD 18304
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca