Version 5.4
Homo sapiens Protein: HYAL4
Summary
InnateDB Protein IDBP-473373.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HYAL4
Protein Name hyaluronoglucosaminidase 4
Synonyms CSHY;
Species Homo sapiens
Ensembl Protein ENSP00000417186
InnateDB Gene IDBG-39012 (HYAL4)
Protein Structure
UniProt Annotation
Function Endo-hyaluronidase that degrades hyaluronan to smaller oligosaccharide fragments. Has also chondroitin sulfate hydrolase activity, The best substrate being the galactosaminidic linkage in the sequence of a trisulfated tetrasaccharide. {ECO:0000269PubMed:16104017, ECO:0000269PubMed:19889881}.
Subcellular Localization Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Disease Associations
Tissue Specificity Detected in placenta and skeletal muscle. {ECO:0000269PubMed:10493834}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0004415 hyalurononglucosaminidase activity
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006027 glycosaminoglycan catabolic process
Cellular Component
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR017853 Glycoside hydrolase, superfamily
IPR018155 Hyaluronidase
PFAM PF01630
PRINTS PR00846
PIRSF PIRSF038193
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q2M3T9
PhosphoSite PhosphoSite-Q2M3T9
TrEMBL C9JU18
UniProt Splice Variant
Entrez Gene 23553
UniGene Hs.28673
RefSeq
HUGO HGNC:5323
OMIM 604510
CCDS CCDS5789
HPRD 05148
IMGT
EMBL AB470346 AC006029 AF009010 BC104788 BC104790 CH236947 CH471070
GenPept AAC98883 AAD43186 AAI04789 AAI04791 BAI49593 EAL24331 EAW83603

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca