InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: UMPS

Summary

InnateDB Protein

IDBP-473390.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

UMPS

Protein Name

uridine monophosphate synthetase

Synonyms

OPRT;

Species

Homo sapiens

Ensembl Protein

ENSP00000420754

InnateDB Gene

IDBG-53858 (UMPS)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.

Experimentally validated
Total	17 [view]
Protein-Protein	16 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004588	orotate phosphoribosyltransferase activity
GO:0004590	orotidine-5'-phosphate decarboxylase activity

Biological Process

GO:0006207	'de novo' pyrimidine nucleobase biosynthetic process
GO:0006221	pyrimidine nucleotide biosynthetic process
GO:0008152	metabolic process
GO:0009116	nucleoside metabolic process

Cellular Component

Protein Structure and Domains

PDB ID

InterPro

IPR000836 Phosphoribosyltransferase domain
IPR001754 Orotidine 5\'-phosphate decarboxylase domain
IPR004467 Orotate phosphoribosyl transferase domain
IPR011060 Ribulose-phosphate binding barrel
IPR029057 Phosphoribosyltransferase-like

PFAM

PF00156
PF00215

PRINTS

PIRSF

SMART

SM00934

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite