Version 5.4
Homo sapiens Gene: UMPS
Summary
InnateDB Gene IDBG-53858.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol UMPS
Gene Name uridine monophosphate synthetase
Synonyms OPRT
Species Homo sapiens
Ensembl Gene ENSG00000114491
Encoded Proteins
IDBP-53860
uridine monophosphate synthetase
IDBP-484184
uridine monophosphate synthetase
IDBP-477802
uridine monophosphate synthetase
IDBP-473461
uridine monophosphate synthetase
IDBP-478743
uridine monophosphate synthetase
IDBP-478598
uridine monophosphate synthetase
IDBP-473390
uridine monophosphate synthetase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a uridine 5'-monophosphate synthase. The encoded protein is a bifunctional enzyme that catalyzes the final two steps of the de novo pyrimidine biosynthetic pathway. The first reaction is carried out by the N-terminal enzyme orotate phosphoribosyltransferase which converts orotic acid to orotidine-5'-monophosphate. The terminal reaction is carried out by the C-terminal enzyme OMP decarboxylase which converts orotidine-5'-monophosphate to uridine monophosphate. Defects in this gene are the cause of hereditary orotic aciduria. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]
This gene encodes a uridine 5\'-monophosphate synthase. The encoded protein is a bifunctional enzyme that catalyzes the final two steps of the de novo pyrimidine biosynthetic pathway. The first reaction is carried out by the N-terminal enzyme orotate phosphoribosyltransferase which converts orotic acid to orotidine-5\'-monophosphate. The terminal reaction is carried out by the C-terminal enzyme OMP decarboxylase which converts orotidine-5\'-monophosphate to uridine monophosphate. Defects in this gene are the cause of hereditary orotic aciduria. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:124730366-124745193
Strand Forward strand
Band q21.2
Transcripts
ENST00000232607 ENSP00000232607
ENST00000462091 ENSP00000417893
ENST00000467167 ENSP00000419618
ENST00000474588 ENSP00000420348
ENST00000497791 ENSP00000419121
ENST00000460034 ENSP00000420409
ENST00000479719 ENSP00000420754
ENST00000498715
ENST00000487622
ENST00000495751
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
Experimentally validated
Total 17 [view]
Protein-Protein 16 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004588 orotate phosphoribosyltransferase activity
GO:0004590 orotidine-5'-phosphate decarboxylase activity
GO:0016740 transferase activity
Biological Process
GO:0006206 pyrimidine nucleobase metabolic process
GO:0006207 'de novo' pyrimidine nucleobase biosynthetic process
GO:0006221 pyrimidine nucleotide biosynthetic process
GO:0006222 UMP biosynthetic process
GO:0007565 female pregnancy
GO:0007595 lactation
GO:0008152 metabolic process
GO:0009116 nucleoside metabolic process
GO:0035690 cellular response to drug
GO:0044205 'de novo' UMP biosynthetic process
GO:0044281 small molecule metabolic process
GO:0046134 pyrimidine nucleoside biosynthetic process
GO:0055086 nucleobase-containing small molecule metabolic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000022814
View Gene Order
ENSBTAG00000013727
Not yet available
Pathways
NETPATH
REACTOME
REACT_21376
Pyrimidine biosynthesis pathway
REACT_1698
Metabolism of nucleotides pathway
REACT_957
Pyrimidine metabolism pathway
REACT_111217
Metabolism pathway
KEGG
hsa00240
Pyrimidine metabolism pathway
hsa00983
Drug metabolism pathway
INOH
INOH website
Pyrimidine nucleotides nucleosides metabolism pathway
INOH website
Pentose phosphate cycle pathway
PID NCI
Cross-References
SwissProt
TrEMBL F2Z303
UniProt Splice Variant
Entrez Gene 7372
UniGene Hs.2057 Hs.598373 Hs.707101
RefSeq NM_000373
HUGO HGNC:12563
OMIM 613891
CCDS CCDS3029
HPRD 02022
IMGT
EMBL AC022336
GenPept
RNA Seq Atlas 7372

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca