InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GRM8

Summary

InnateDB Protein

IDBP-473403.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GRM8

Protein Name

glutamate receptor, metabotropic 8

Synonyms

GLUR8; GPRC1H; mGlu8; MGLUR8;

Species

Homo sapiens

Ensembl Protein

ENSP00000419832

InnateDB Gene

IDBG-39195 (GRM8)

Protein Structure

UniProt Annotation

Function

G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. {ECO:0000269PubMed:9473604}.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001642	group III metabotropic glutamate receptor activity
GO:0004930	G-protein coupled receptor activity
GO:0008066	glutamate receptor activity

Biological Process

GO:0007186	G-protein coupled receptor signaling pathway
GO:0007196	adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway
GO:0007601	visual perception
GO:0007608	sensory perception of smell
GO:0030818	negative regulation of cAMP biosynthetic process
GO:0051966	regulation of synaptic transmission, glutamatergic

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016021	integral component of membrane
GO:0042734	presynaptic membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000144 GPCR, family 3, metabotropic glutamate receptor 8
IPR000162 GPCR, family 3, metabotropic glutamate receptor
IPR000337 GPCR, family 3
IPR001786 GPCR, family 3, metabotropic glutamate receptor 4
IPR001828 Extracellular ligand-binding receptor
IPR011500 GPCR, family 3, nine cysteines domain
IPR017978 GPCR, family 3, C-terminal
IPR028082 Periplasmic binding protein-like I

PFAM

PF01094
PF07562
PF00003

PRINTS

PR01058
PR00593
PR00248
PR01054

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O00222