InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: GRM8

Summary

InnateDB Gene

IDBG-39195.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GRM8

Gene Name

glutamate receptor, metabotropic 8

Synonyms

GLUR8; GPRC1H; mGlu8; MGLUR8

Species

Homo sapiens

Ensembl Gene

ENSG00000179603

Encoded Proteins

IDBP-39197

glutamate receptor, metabotropic 8

IDBP-39199

glutamate receptor, metabotropic 8

IDBP-39201

glutamate receptor, metabotropic 8

IDBP-386034

glutamate receptor, metabotropic 8

IDBP-386036

glutamate receptor, metabotropic 8

IDBP-386039

glutamate receptor, metabotropic 8

IDBP-473403

glutamate receptor, metabotropic 8

IDBP-474659

glutamate receptor, metabotropic 8

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:126438598-127253294

Strand

Reverse strand

Band

q31.33

Transcripts

ENST00000358373	ENSP00000351142
ENST00000341617	ENSP00000345747
ENST00000339582	ENSP00000344173
ENST00000448250
ENST00000444921	ENSP00000409790
ENST00000457830	ENSP00000415522
ENST00000412160	ENSP00000398012
ENST00000489939
ENST00000495315
ENST00000472701	ENSP00000419832
ENST00000480995
ENST00000465844	ENSP00000418255
ENST00000465800
ENST00000473254

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001642	group III metabotropic glutamate receptor activity
GO:0004930	G-protein coupled receptor activity
GO:0008066	glutamate receptor activity

Biological Process

GO:0007186	G-protein coupled receptor signaling pathway
GO:0007196	adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway
GO:0007601	visual perception
GO:0007608	sensory perception of smell
GO:0030818	negative regulation of cAMP biosynthetic process
GO:0051966	regulation of synaptic transmission, glutamatergic

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016021	integral component of membrane
GO:0042734	presynaptic membrane

Orthologs

Species

Mus musculus

Gene ID

Gene Order

ENSMUSG00000024211

View Gene Order

Pathways

NETPATH

REACTOME

REACT_19231

G alpha (i) signalling events pathway

REACT_18319

Class C/3 (Metabotropic glutamate/pheromone receptors) pathway

REACT_14797

Signaling by GPCR pathway

REACT_111102

Signal Transduction pathway

REACT_19184

GPCR downstream signaling pathway

REACT_21340

GPCR ligand binding pathway

KEGG

hsa04080

Neuroactive ligand-receptor interaction pathway

INOH

INOH website

GPCR signaling pathway

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.449625 Hs.693003

RefSeq

NM_000845 NM_001127323 XM_006715938

HUGO

OMIM

CCDS

CCDS47696 CCDS5794

HPRD

03071

IMGT

EMBL

GenPept

RNA Seq Atlas