InnateDB Protein
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IDBP-473627.4
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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CREM
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Protein Name
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cAMP responsive element modulator
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Synonyms
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CREM-2; hCREM-2; ICER;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000417562
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InnateDB Gene
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IDBG-69430 (CREM)
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Protein Structure
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Function |
Transcriptional regulator that binds the cAMP response element (CRE), a sequence present in many viral and cellular promoters. Isoforms are either transcriptional activators or repressors. Plays a role in spermatogenesis and is involved in spermatid maturation (PubMed:10373550). {ECO:0000269PubMed:10373550}.Isoform 6: May play a role in the regulation of the circadian clock: acts as a transcriptional repressor of the core circadian component PER1 by directly binding to cAMP response elements in its promoter. {ECO:0000250}.
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Subcellular Localization |
Nucleus.Isoform 6: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Expressed in testes (round spermatids) (at protein level). Isoform 14 is the major activator form in testes. {ECO:0000269PubMed:11044457, ECO:0000269PubMed:14511788, ECO:0000269PubMed:16143638}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 35 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated |
Total |
35
[view]
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Protein-Protein |
27
[view]
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Protein-DNA |
8
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
5 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR001630
cAMP response element binding (CREB) protein
IPR004827
Basic-leucine zipper domain
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PFAM |
PF00170
PF07716
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PRINTS |
PR00041
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PIRSF |
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SMART |
SM00338
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TIGRFAMs |
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Modification |
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SwissProt |
Q03060
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PhosphoSite |
PhosphoSite-Q03060
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TrEMBL |
E9PAR2
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UniProt Splice Variant |
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Entrez Gene |
1390
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UniGene |
Hs.713133
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RefSeq |
NP_874390
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HUGO |
HGNC:2352
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OMIM |
123812
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CCDS |
CCDS7188
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HPRD |
00444
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IMGT |
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EMBL |
AF069065
AF212158
AF213897
AF213898
AF213899
AF214665
AF217318
AF417234
AK289379
AK290612
AK291566
AK301906
AL117336
AL157783
AY292864
BC017117
BC066342
BC090051
CH471072
D14825
D14826
S68134
S68271
U44836
Z15159
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GenPept |
AAB03751
AAC19383
AAC60616
AAC60617
AAF66158
AAF68266
AAF68682
AAH17117
AAH66342
AAH90051
AAN32656
AAP44115
BAA03562
BAA03564
BAA03565
BAA03566
BAA03567
BAF82068
BAF83301
BAF84255
BAG63333
CAA78858
EAW85917
EAW85918
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