InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CRHR2

Summary

InnateDB Protein

IDBP-473744.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CRHR2

Protein Name

corticotropin releasing hormone receptor 2

Synonyms

CRF-RB; CRF2; CRFR2; HM-CRF;

Species

Homo sapiens

Ensembl Protein

ENSP00000418722

InnateDB Gene

IDBG-11186 (CRHR2)

Protein Structure

UniProt Annotation

Function

G-protein coupled receptor for CRH (corticotropin- releasing factor), UCN (urocortin), UCN2 and UCN3. Has high affinity for UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:22689579}; Multi-pass membrane protein {ECO:0000269PubMed:22689579}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004888	transmembrane signaling receptor activity
GO:0004930	G-protein coupled receptor activity
GO:0005515	protein binding

Biological Process

GO:0007166	cell surface receptor signaling pathway
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007188	adenylate cyclase-modulating G-protein coupled receptor signaling pathway

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000832 GPCR, family 2, secretin-like
IPR001879 GPCR, family 2, extracellular hormone receptor domain
IPR002001 GPCR, family 2, diuretic hormone receptor
IPR003051 GPCR, family 2, corticotropin releasing factor receptor
IPR003053 GPCR, family 2, corticotropin releasing factor receptor, type 2
IPR017981 GPCR, family 2-like

PFAM

PF00002
PF02793

PRINTS

PR00249
PR01127
PR01279
PR01281

PIRSF

SMART

SM00008

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt