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InnateDB Protein
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IDBP-473774.4
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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POLR2J3
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Protein Name
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polymerase (RNA) II (DNA directed) polypeptide J3
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000425877
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InnateDB Gene
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IDBG-13924 (POLR2J3)
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Protein Structure
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| Function |
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB11 is part of the core element with the central large cleft (By similarity). {ECO:0000250}.
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| Subcellular Localization |
Nucleus {ECO:0000250}.
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| Disease Associations |
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| Tissue Specificity |
Ubiquitously expressed. {ECO:0000269PubMed:11747469}.
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| Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
| Experimentally validated |
| Total |
1
[view]
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| Protein-Protein |
1
[view]
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| Protein-DNA |
0
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| Protein-RNA |
0
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| DNA-DNA |
0
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| RNA-RNA |
0
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| DNA-RNA |
0
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Molecular Function |
| Accession |
GO Term |
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GO:0046983
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protein dimerization activity
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| Biological Process |
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| Cellular Component |
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| PDB ID |
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| InterPro |
IPR009025
DNA-directed RNA polymerase, RBP11-like dimerisation domain
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| PFAM |
PF01193
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| PRINTS |
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| PIRSF |
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| SMART |
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| TIGRFAMs |
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| Modification |
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| SwissProt |
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| PhosphoSite |
PhosphoSite-Q9GZM3
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| TrEMBL |
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| UniProt Splice Variant |
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| Entrez Gene |
548644
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| UniGene |
Hs.732239
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| RefSeq |
XP_006716095
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| HUGO |
HGNC:33853
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| OMIM |
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| CCDS |
CCDS47673
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| HPRD |
18684
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| IMGT |
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| EMBL |
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| GenPept |
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Version 5.4