InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ST3GAL1

Summary

InnateDB Protein

IDBP-473935.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ST3GAL1

Protein Name

ST3 beta-galactoside alpha-2,3-sialyltransferase 1

Synonyms

Gal-NAc6S; SIAT4A; SIATFL; ST3GalA; ST3GalA.1; ST3GalIA; ST3GalIA,1; ST3O;

Species

Homo sapiens

Ensembl Protein

ENSP00000430515

InnateDB Gene

IDBG-36530 (ST3GAL1)

Protein Structure

UniProt Annotation

Function

It may be responsible for the synthesis of the sequence NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc- found on sugar chains O- linked to Thr or Ser and also as a terminal sequence on certain gangliosides. SIAT4A and SIAT4B sialylate the same acceptor substrates but exhibit different Km values.

Subcellular Localization

Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Secreted. Note=Membrane- bound form in trans cisternae of Golgi. Secreted into the body fluid.

Disease Associations

Tissue Specificity

Expressed in several tissues. Highest expression in lung, liver, skeletal muscle, kidney, pancreas, spleen and placenta.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	1 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003836	beta-galactoside (CMP) alpha-2,3-sialyltransferase activity
GO:0008373	sialyltransferase activity

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0006054	N-acetylneuraminate metabolic process
GO:0006464	cellular protein modification process
GO:0006486	protein glycosylation
GO:0006487	protein N-linked glycosylation
GO:0016266	O-glycan processing
GO:0018146	keratan sulfate biosynthetic process
GO:0030203	glycosaminoglycan metabolic process
GO:0042339	keratan sulfate metabolic process
GO:0043687	post-translational protein modification
GO:0044267	cellular protein metabolic process
GO:0044281	small molecule metabolic process
GO:0097503	sialylation

Cellular Component

GO:0000139	Golgi membrane
GO:0005794	Golgi apparatus
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030173	integral component of Golgi membrane
GO:0032580	Golgi cisterna membrane
GO:0070062	extracellular vesicular exosome