Version 5.4
Homo sapiens Gene: ST3GAL1
Summary
InnateDB Gene IDBG-36530.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ST3GAL1
Gene Name ST3 beta-galactoside alpha-2,3-sialyltransferase 1
Synonyms Gal-NAc6S; SIAT4A; SIATFL; ST3GalA; ST3GalA.1; ST3GalIA; ST3GalIA,1; ST3O
Species Homo sapiens
Ensembl Gene ENSG00000008513
Encoded Proteins
IDBP-376680
ST3 beta-galactoside alpha-2,3-sialyltransferase 1
IDBP-481410
ST3 beta-galactoside alpha-2,3-sialyltransferase 1
IDBP-473935
ST3 beta-galactoside alpha-2,3-sialyltransferase 1
IDBP-484726
ST3 beta-galactoside alpha-2,3-sialyltransferase 1
IDBP-481139
ST3 beta-galactoside alpha-2,3-sialyltransferase 1
IDBP-478140
ST3 beta-galactoside alpha-2,3-sialyltransferase 1
IDBP-477138
ST3 beta-galactoside alpha-2,3-sialyltransferase 1
IDBP-479228
ST3 beta-galactoside alpha-2,3-sialyltransferase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates. The encoded protein is normally found in the Golgi but can be proteolytically processed to a soluble form. Correct glycosylation of the encoded protein may be critical to its sialyltransferase activity. This protein, which is a member of glycosyltransferase family 29, can use the same acceptor substrates as does sialyltransferase 4B. Two transcript variants encoding the same protein have been found for this gene. Other transcript variants may exist, but have not been fully characterized yet. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:133454848-133571940
Strand Reverse strand
Band q24.22
Transcripts
ENST00000399640 ENSP00000414073
ENST00000521180 ENSP00000428540
ENST00000522652 ENSP00000430515
ENST00000523854 ENSP00000429638
ENST00000517668 ENSP00000427720
ENST00000522204
ENST00000523634 ENSP00000429936
ENST00000519924 ENSP00000430135
ENST00000523855 ENSP00000427786
ENST00000519435
ENST00000518298
ENST00000520020
ENST00000522873
ENST00000521627
ENST00000522285
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 1 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003836 beta-galactoside (CMP) alpha-2,3-sialyltransferase activity
GO:0008373 sialyltransferase activity
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006054 N-acetylneuraminate metabolic process
GO:0006464 cellular protein modification process
GO:0006468 protein phosphorylation
GO:0006486 protein glycosylation
GO:0006487 protein N-linked glycosylation
GO:0016266 O-glycan processing
GO:0018146 keratan sulfate biosynthetic process
GO:0030203 glycosaminoglycan metabolic process
GO:0042339 keratan sulfate metabolic process
GO:0043687 post-translational protein modification
GO:0044267 cellular protein metabolic process
GO:0044281 small molecule metabolic process
GO:0097503 sialylation
Cellular Component
GO:0000139 Golgi membrane
GO:0005794 Golgi apparatus
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030173 integral component of Golgi membrane
GO:0032580 Golgi cisterna membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000013846
View Gene Order
ENSBTAG00000001156
Not yet available
Pathways
NETPATH
REACTOME
REACT_115835
Termination of O-glycan biosynthesis pathway
REACT_115606
O-linked glycosylation of mucins pathway
REACT_22433
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein pathway
REACT_22426
Asparagine N-linked glycosylation pathway
REACT_121120
Keratan sulfate biosynthesis pathway
REACT_147853
Mucopolysaccharidoses pathway
REACT_22161
Post-translational protein modification pathway
REACT_200783
Myoclonic epilepsy of Lafora pathway
REACT_267711
Defective B4GALT7 causes EDS, progeroid type pathway
REACT_267713
Defective CHST6 causes MCDC1 pathway
REACT_121288
Keratan sulfate/keratin metabolism pathway
REACT_147719
MPS VI - Maroteaux-Lamy syndrome pathway
REACT_267645
Defective PAPSS2 causes SEMD-PA pathway
REACT_474
Metabolism of carbohydrates pathway
REACT_147749
MPS IIID - Sanfilippo syndrome D pathway
REACT_22387
Synthesis of substrates in N-glycan biosythesis pathway
REACT_267662
Defective SLC26A2 causes chondrodysplasias pathway
REACT_200727
O-linked glycosylation pathway
REACT_200874
Sialic acid metabolism pathway
REACT_147739
MPS IX - Natowicz syndrome pathway
REACT_267674
Defective EXT1 causes exostoses 1, TRPS2 and CHDS pathway
REACT_17015
Metabolism of proteins pathway
REACT_267642
Defective CHST14 causes EDS, musculocontractural type pathway
REACT_147798
MPS IV - Morquio syndrome B pathway
REACT_267659
Defective B3GAT3 causes JDSSDHD pathway
REACT_267708
Defective CHST3 causes SEDCJD pathway
REACT_147825
MPS IV - Morquio syndrome A pathway
REACT_267654
Defective EXT2 causes exostoses 2 pathway
REACT_267707
Diseases associated with glycosaminoglycan metabolism pathway
REACT_147734
MPS II - Hunter syndrome pathway
REACT_267635
Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) pathway
REACT_121315
Glycosaminoglycan metabolism pathway
REACT_267705
Diseases of glycosylation pathway
REACT_147759
MPS VII - Sly syndrome pathway
REACT_267682
Defective CHSY1 causes TPBS pathway
REACT_111217
Metabolism pathway
REACT_147857
MPS I - Hurler syndrome pathway
REACT_147753
MPS IIIA - Sanfilippo syndrome A pathway
REACT_147860
MPS IIIC - Sanfilippo syndrome C pathway
REACT_116125
Disease pathway
REACT_200833
Glycogen storage diseases pathway
REACT_147788
MPS IIIB - Sanfilippo syndrome B pathway
KEGG
hsa00604
Glycosphingolipid biosynthesis pathway
hsa00512
Mucin type O-Glycan biosynthesis pathway
hsa00533
Glycosaminoglycan biosynthesis pathway
hsa00603
Glycosphingolipid biosynthesis pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.374257 Hs.714208 Hs.736266
RefSeq NM_003033 NM_173344 XM_005251023 XM_005251024 XM_005251025 XM_006716617
HUGO
OMIM
CCDS CCDS6373
HPRD 06219
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca