InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CNOT6L

Summary

InnateDB Protein

IDBP-474033.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CNOT6L

Protein Name

CCR4-NOT transcription complex, subunit 6-like

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000424896

InnateDB Gene

IDBG-25831 (CNOT6L)

Protein Structure

UniProt Annotation

Function

Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. May be involved in the deadenylation-dependent degradation of mRNAs through the 3'-UTR AU-rich element-mediated mechanism. Involved in deadenylation-dependent degradation of CDKN1B mRNA. Its mRNA deadenylase activity can be inhibited by TOB1. Mediates cell proliferation and cell survival and prevents cellular senescence. {ECO:0000269PubMed:17452450, ECO:0000269PubMed:21233283}.

Subcellular Localization

Cytoplasm. Nucleus.

Disease Associations

Tissue Specificity

Highly expressed in placenta, skeletal muscle, pancreas, testis and leukocytes. Weakly expressed in heart, spleen and thymus. {ECO:0000269PubMed:17452450}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	23 [view]
Protein-Protein	23 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004535	poly(A)-specific ribonuclease activity
GO:0005515	protein binding
GO:0046872	metal ion binding

Biological Process

GO:0000288	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO:0000289	nuclear-transcribed mRNA poly(A) tail shortening
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006417	regulation of translation
GO:0008284	positive regulation of cell proliferation
GO:0010467	gene expression
GO:0010606	positive regulation of cytoplasmic mRNA processing body assembly
GO:0016070	RNA metabolic process
GO:0016071	mRNA metabolic process
GO:0031047	gene silencing by RNA
GO:0061157	mRNA destabilization
GO:0090503	RNA phosphodiester bond hydrolysis, exonucleolytic