InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SMYD3

Summary

InnateDB Protein

IDBP-474107.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SMYD3

Protein Name

SET and MYND domain containing 3

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000419184

InnateDB Gene

IDBG-107832 (SMYD3)

Protein Structure

UniProt Annotation

Function

Histone methyltransferase. Specifically methylates 'Lys- 4' and 'Lys-5' of histone H3, inducing di- and tri-methylation, but not monomethylation. Plays an important role in transcriptional activation as a member of an RNA polymerase complex. Binds DNA containing 5'-CCCTCC-3' or 5'-GAGGGG-3' sequences. {ECO:0000269PubMed:15235609, ECO:0000269PubMed:22419068}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:15235609}. Nucleus {ECO:0000269PubMed:15235609}. Note=Mainly cytoplasmic when cells are arrested at G0/G1. Accumulates in the nucleus at S phase and G2/M.

Disease Associations

Tissue Specificity

Expressed in skeletal muscles and testis. Overexpressed in a majority of colorectal and hepatocellular carcinomas. {ECO:0000269PubMed:15235609}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	26 [view]
Protein-Protein	24 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	2 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding
GO:0000993	RNA polymerase II core binding
GO:0001162	RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding
GO:0005515	protein binding
GO:0018024	histone-lysine N-methyltransferase activity
GO:0046872	metal ion binding

Biological Process

GO:0006334	nucleosome assembly
GO:0006469	negative regulation of protein kinase activity
GO:0014904	myotube cell development
GO:0033138	positive regulation of peptidyl-serine phosphorylation
GO:0034968	histone lysine methylation
GO:0045184	establishment of protein localization
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0071549	cellular response to dexamethasone stimulus