InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PDGFC

Summary

InnateDB Protein

IDBP-474152.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PDGFC

Protein Name

platelet derived growth factor C

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000422464

InnateDB Gene

IDBG-42546 (PDGFC)

Protein Structure

UniProt Annotation

Function

Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen and chemoattractant for cells of mesenchymal origin. Required for normal skeleton formation during embryonic development, especially for normal development of the craniofacial skeleton and for normal development of the palate. Required for normal skin morphogenesis during embryonic development. Plays an important role in wound healing, where it appears to be involved in three stages: inflammation, proliferation and remodeling. Plays an important role in angiogenesis and blood vessel development. Involved in fibrotic processes, in which transformation of interstitial fibroblasts into myofibroblasts plus collagen deposition occurs. The CUB domain has mitogenic activity in coronary artery smooth muscle cells, suggesting a role beyond the maintenance of the latency of the PDGF domain. In the nucleus, PDGFC seems to have additional function. {ECO:0000269PubMed:10806482, ECO:0000269PubMed:10858496, ECO:0000269PubMed:11297552, ECO:0000269PubMed:11854040, ECO:0000269PubMed:12032822, ECO:0000269PubMed:15061151, ECO:0000269PubMed:15372073, ECO:0000269PubMed:15389578, ECO:0000269PubMed:15728360, ECO:0000269PubMed:15911618, ECO:0000269PubMed:16439802, ECO:0000269PubMed:18055825}.

Subcellular Localization

Cytoplasm. Secreted. Nucleus. Cytoplasmic granule. Note=Sumoylated form is predominant in the nucleus. Stored in alpha granules in platelets. Membrane associated when bound to receptors.

Disease Associations

Tissue Specificity

Expressed in the fallopian tube, vascular smooth muscle cells in kidney, breast and colon and in visceral smooth muscle of the gastrointestinal tract. Highly expressed in retinal pigment epithelia. Expressed in medulloblastoma. In the kidney, constitutively expressed in parietal epithelial cells of Bowman's capsule, tubular epithelial cells and in arterial endothelial cells (at protein level). Highly expressed in the platelets, prostate, testis and uterus. Higher expression is observed in uterine leiomyomata. Weaker expression in the spleen, thymus, heart, pancreas, liver, ovary cells and small intestine, and negligible expression in the colon and peripheral blood leukocytes. {ECO:0000269PubMed:10806482, ECO:0000269PubMed:11004490, ECO:0000269PubMed:11297552, ECO:0000269PubMed:11342471, ECO:0000269PubMed:11854040, ECO:0000269PubMed:12176024, ECO:0000269PubMed:15061151, ECO:0000269PubMed:17482170, ECO:0000269PubMed:18055825}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.

Experimentally validated
Total	9 [view]
Protein-Protein	8 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005161	platelet-derived growth factor receptor binding
GO:0005515	protein binding
GO:0008083	growth factor activity
GO:0042803	protein homodimerization activity

Biological Process

GO:0007171	activation of transmembrane receptor protein tyrosine kinase activity
GO:0007417	central nervous system development
GO:0008284	positive regulation of cell proliferation
GO:0009887	organ morphogenesis
GO:0045740	positive regulation of DNA replication
GO:0048008	platelet-derived growth factor receptor signaling pathway
GO:0048146	positive regulation of fibroblast proliferation
GO:0050730	regulation of peptidyl-tyrosine phosphorylation
GO:0051781	positive regulation of cell division
GO:0071230	cellular response to amino acid stimulus

Cellular Component

GO:0000139	Golgi membrane
GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005788	endoplasmic reticulum lumen
GO:0005886	plasma membrane
GO:0009986	cell surface
GO:0016020	membrane
GO:0070062	extracellular vesicular exosome