InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CLIC3

Summary

InnateDB Protein

IDBP-474232.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CLIC3

Protein Name

chloride intracellular channel 3

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000419378

InnateDB Gene

IDBG-92947 (CLIC3)

Protein Structure

UniProt Annotation

Function

Can insert into membranes and form chloride ion channels. May participate in cellular growth control. {ECO:0000269PubMed:9880541}.

Subcellular Localization

Nucleus. Membrane; Single-pass membrane protein. Cytoplasm. Note=Predominantly nuclear. Some protein was found in the cytoplasm. Exists both as soluble cytoplasmic protein and as membrane protein with probably a single transmembrane domain (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Detected in placenta (at protein level). Widely expressed. High expression is found in placenta followed by lung and heart. Low expression in skeletal muscle, kidney and pancreas. {ECO:0000269PubMed:17027078, ECO:0000269PubMed:9880541}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005247	voltage-gated chloride channel activity
GO:0005254	chloride channel activity
GO:0005515	protein binding

Biological Process

GO:0006821	chloride transport
GO:0007165	signal transduction
GO:0034765	regulation of ion transmembrane transport
GO:0044070	regulation of anion transport
GO:1902476	chloride transmembrane transport