Version 5.4
Homo sapiens Gene: CLIC3
Summary
InnateDB Gene IDBG-92947.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CLIC3
Gene Name chloride intracellular channel 3
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000169583
Encoded Proteins
IDBP-474232
chloride intracellular channel 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 3 is a member of the p64 family and is predominantly localized in the nucleus and stimulates chloride ion channel activity. In addition, this protein may participate in cellular growth control, based on its association with ERK7, a member of the MAP kinase family. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:136994635-136996803
Strand Reverse strand
Band q34.3
Transcripts
ENST00000494426 ENSP00000419378
ENST00000480181
ENST00000473911
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005247 voltage-gated chloride channel activity
GO:0005254 chloride channel activity
GO:0005515 protein binding
Biological Process
GO:0006821 chloride transport
GO:0007165 signal transduction
GO:0034765 regulation of ion transmembrane transport
GO:0044070 regulation of anion transport
GO:1902476 chloride transmembrane transport
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0016020 membrane
GO:0034707 chloride channel complex
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000015093
View Gene Order
ENSBTAG00000015085
Not yet available
Cross-References
SwissProt O95833
TrEMBL Q5SQ17 Q6FGP1
UniProt Splice Variant
Entrez Gene 9022
UniGene
RefSeq NM_004669 XM_005266117
HUGO HGNC:2064
OMIM 606533
CCDS CCDS7021
HPRD
IMGT
EMBL AF102166 AL807752 BC007012 CH471090 CR542066
GenPept AAD16450 AAH07012 CAG46863 CAI12764 EAW88329 EAW88330
RNA Seq Atlas 9022

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca