InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: OPRM1

Summary

InnateDB Protein

IDBP-474307.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

OPRM1

Protein Name

opioid receptor, mu 1

Synonyms

LMOR; M-OR-1; MOP; MOR; MOR1; OPRM;

Species

Homo sapiens

Ensembl Protein

ENSP00000430575

InnateDB Gene

IDBG-98194 (OPRM1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	20 [view]
Protein-Protein	20 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001965	G-protein alpha-subunit binding
GO:0004930	G-protein coupled receptor activity
GO:0004979	beta-endorphin receptor activity
GO:0005245	voltage-gated calcium channel activity
GO:0005515	protein binding
GO:0038047	morphine receptor activity

Biological Process

GO:0007187	G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GO:0007194	negative regulation of adenylate cyclase activity
GO:0007200	phospholipase C-activating G-protein coupled receptor signaling pathway
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0007218	neuropeptide signaling pathway
GO:0007600	sensory perception
GO:0008285	negative regulation of cell proliferation
GO:0019233	sensory perception of pain
GO:0033554	cellular response to stress
GO:0043950	positive regulation of cAMP-mediated signaling
GO:0043951	negative regulation of cAMP-mediated signaling
GO:0045019	negative regulation of nitric oxide biosynthetic process
GO:0045429	positive regulation of nitric oxide biosynthetic process
GO:0048149	behavioral response to ethanol
GO:0050769	positive regulation of neurogenesis
GO:0051481	negative regulation of cytosolic calcium ion concentration
GO:0061358	negative regulation of Wnt protein secretion
GO:0070374	positive regulation of ERK1 and ERK2 cascade
GO:0070588	calcium ion transmembrane transport
GO:2000310	regulation of N-methyl-D-aspartate selective glutamate receptor activity