Version 5.4
Homo sapiens Gene: OPRM1
Summary
InnateDB Gene IDBG-98194.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol OPRM1
Gene Name opioid receptor, mu 1
Synonyms LMOR; M-OR-1; MOP; MOR; MOR1; OPRM
Species Homo sapiens
Ensembl Gene ENSG00000112038
Encoded Proteins
IDBP-98196
opioid receptor, mu 1
IDBP-98198
opioid receptor, mu 1
IDBP-98200
opioid receptor, mu 1
IDBP-98202
opioid receptor, mu 1
IDBP-387958
opioid receptor, mu 1
IDBP-387960
opioid receptor, mu 1
IDBP-387966
opioid receptor, mu 1
IDBP-387970
opioid receptor, mu 1
IDBP-387975
opioid receptor, mu 1
IDBP-387977
opioid receptor, mu 1
IDBP-478646
opioid receptor, mu 1
IDBP-482514
opioid receptor, mu 1
IDBP-475686
opioid receptor, mu 1
IDBP-484411
opioid receptor, mu 1
IDBP-474307
opioid receptor, mu 1
IDBP-482473
opioid receptor, mu 1
IDBP-475668
opioid receptor, mu 1
IDBP-476401
opioid receptor, mu 1
IDBP-482124
opioid receptor, mu 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes one of three opioid receptors. The mu opioid receptor is the principal target of endogenous opioid peptides and opioid analgesic agents such a s beta-endorphn and enkephalins. The NM_001008503.1:c.118A>G allele had been associated with opioid and alcohol addiction and variations in pain sensitivity but evidence is conflicting. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2012]
This gene encodes one of at least three opioid receptors in humans; the mu opioid receptor (MOR). The MOR is the principal target of endogenous opioid peptides and opioid analgesic agents such as beta-endorphin and enkephalins. The MOR also has an important role in dependence to other drugs of abuse, such as nicotine, cocaine, and alcohol via its modulation of the dopamine system. The NM_001008503.2:c.118A>G allele has been associated with opioid and alcohol addiction and variations in pain sensitivity but evidence for it having a causal role is conflicting. Multiple transcript variants encoding different isoforms have been found for this gene. Though the canonical MOR belongs to the superfamily of 7-transmembrane-spanning G-protein-coupled receptors some isoforms of this gene have only 6 transmembrane domains. [provided by RefSeq, Oct 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:154010496-154246867
Strand Forward strand
Band q25.2
Transcripts
ENST00000337049 ENSP00000338381
ENST00000330432 ENSP00000328264
ENST00000229768 ENSP00000229768
ENST00000360422 ENSP00000353598
ENST00000434900 ENSP00000394624
ENST00000452687 ENSP00000410497
ENST00000435918 ENSP00000413752
ENST00000419506 ENSP00000403549
ENST00000428397 ENSP00000411903
ENST00000414028 ENSP00000399359
ENST00000520282 ENSP00000430247
ENST00000520708 ENSP00000430876
ENST00000518759 ENSP00000430260
ENST00000523520
ENST00000522739 ENSP00000428018
ENST00000524150 ENSP00000430575
ENST00000524163 ENSP00000430097
ENST00000519083 ENSP00000431048
ENST00000519613
ENST00000522555 ENSP00000429719
ENST00000522236 ENSP00000429373
ENST00000522382
ENST00000521106
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 20 [view]
Protein-Protein 20 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001965 G-protein alpha-subunit binding
GO:0004930 G-protein coupled receptor activity
GO:0004979 beta-endorphin receptor activity
GO:0004985 opioid receptor activity
GO:0005245 voltage-gated calcium channel activity
GO:0005515 protein binding
GO:0019904 protein domain specific binding
GO:0031005 filamin binding
GO:0031681 G-protein beta-subunit binding
GO:0038047 morphine receptor activity
Biological Process
GO:0002438 acute inflammatory response to antigenic stimulus
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway
GO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
GO:0007194 negative regulation of adenylate cyclase activity
GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007218 neuropeptide signaling pathway
GO:0007600 sensory perception
GO:0007626 locomotory behavior
GO:0008285 negative regulation of cell proliferation
GO:0019233 sensory perception of pain
GO:0031635 adenylate cyclase-inhibiting opioid receptor signaling pathway
GO:0032094 response to food
GO:0032100 positive regulation of appetite
GO:0032496 response to lipopolysaccharide
GO:0033554 cellular response to stress
GO:0038003 opioid receptor signaling pathway
GO:0042060 wound healing
GO:0042220 response to cocaine
GO:0043278 response to morphine
GO:0043950 positive regulation of cAMP-mediated signaling
GO:0043951 negative regulation of cAMP-mediated signaling
GO:0045019 negative regulation of nitric oxide biosynthetic process
GO:0045429 positive regulation of nitric oxide biosynthetic process
GO:0048149 behavioral response to ethanol
GO:0050769 positive regulation of neurogenesis
GO:0051481 negative regulation of cytosolic calcium ion concentration
GO:0051930 regulation of sensory perception of pain
GO:0060079 regulation of excitatory postsynaptic membrane potential
GO:0061358 negative regulation of Wnt protein secretion
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0070588 calcium ion transmembrane transport
GO:0070848 response to growth factor
GO:0071315 cellular response to morphine
GO:2000310 regulation of N-methyl-D-aspartate selective glutamate receptor activity
Cellular Component
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005925 focal adhesion
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030425 dendrite
GO:0032590 dendrite membrane
GO:0032839 dendrite cytoplasm
GO:0042383 sarcolemma
GO:0043204 perikaryon
GO:0045121 membrane raft
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000000766
View Gene Order
ENSBTAG00000019719
Not yet available
Pathways
NETPATH
REACTOME
REACT_19231
G alpha (i) signalling events pathway
REACT_14819
Peptide ligand-binding receptors pathway
REACT_14828
Class A/1 (Rhodopsin-like receptors) pathway
REACT_15457
G-protein activation pathway
REACT_15295
Opioid Signalling pathway
REACT_14797
Signaling by GPCR pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
REACT_21340
GPCR ligand binding pathway
KEGG
hsa04080
Neuroactive ligand-receptor interaction pathway
INOH
PID NCI
il4_2pathway
IL4-mediated signaling events
Cross-References
SwissProt P35372
TrEMBL B8K2Q5 C9E9Z9 C9EA00 Q71V90 Q7Z6A5
UniProt Splice Variant
Entrez Gene 4988
UniGene Hs.2353
RefSeq NM_001008504 NM_000914 NM_001008503 NM_001008505 NM_001145279 NM_001145280 NM_001145281 NM_001145282 NM_001145283 NM_001145284 NM_001145285 NM_001145286 NM_001145287 NM_001285523 NM_001285524 NM_001285526 NM_001285528 XM_006715496
HUGO HGNC:8156
OMIM 600018
CCDS CCDS47508 CCDS43517 CCDS43518 CCDS47503 CCDS47504 CCDS47505 CCDS47506 CCDS47507 CCDS55068 CCDS55069 CCDS55070 CCDS55071
HPRD 02484
IMGT
EMBL AF024516 AF153500 AK313901 AL132774 AL136444 AL445220 AY036622 AY036623 AY195733 AY225404 AY292290 AY292291 AY299483 AY309001 AY309005 AY309006 AY309007 AY309008 AY309009 AY364230 AY364890 AY521028 AY587764 BC074927 CH471051 DQ680044 EU340241 EU340242 EU340243 EU360599 EU362990 FJ041292 FJ041293 FJ041294 GQ478709 GQ478710 HQ699462 L25119 L29301 U12569
GenPept AAA20580 AAA73958 AAB60354 AAC51878 AAD44318 AAH74927 AAK74189 AAK74190 AAO21305 AAP44409 AAP44410 AAP44727 AAP58255 AAQ77385 AAQ77389 AAQ77390 AAQ77391 AAQ77392 AAQ77393 AAR11568 AAR12887 AAS00462 AAS83107 ABH03503 ABY61366 ABY66530 ACA49726 ACA49727 ACA49728 ACM90350 ACM90351 ACM90352 ACV85685 ACV85686 AET97615 BAG36624 CAI20458 EAW47705
RNA Seq Atlas 4988

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca