Version 5.4
Homo sapiens Protein: RGS8
Summary
InnateDB Protein IDBP-474414.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RGS8
Protein Name regulator of G-protein signaling 8
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000426289
InnateDB Gene IDBG-105256 (RGS8)
Protein Structure
UniProt Annotation
Function Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Preferentially binds to G(o)-alpha and G(i)-alpha-3 (By similarity). {ECO:0000250}.
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005096 GTPase activator activity
Biological Process
GO:0008277 regulation of G-protein coupled receptor protein signaling pathway
GO:0038032 termination of G-protein coupled receptor signaling pathway
GO:0043547 positive regulation of GTPase activity
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
Protein Structure and Domains
PDB ID
InterPro IPR000342 Regulator of G protein signalling domain
IPR016137 Regulator of G protein signalling superfamily
PFAM PF00615
PRINTS PR01301
PIRSF
SMART SM00315
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P57771
PhosphoSite PhosphoSite-
TrEMBL D6RD36
UniProt Splice Variant
Entrez Gene 85397
UniGene Hs.458417
RefSeq XP_005245612
HUGO HGNC:16810
OMIM 607189
CCDS CCDS41443
HPRD 06221
IMGT
EMBL AF297015 AF300649 AK294660 AK296514 AL353778 BC069677 BC069718 BC103865 BC103866 BC103867 CH471067
GenPept AAG18443 AAG45337 AAH69677 AAH69718 AAI03866 AAI03867 AAI03868 BAG57830 BAG59146 CAH72421 EAW91130

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca